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p53, Mdm2, and c-Myc overexpression is associated with a poor prognosis in aggressive non-Hodgkin's lymphomas
- Source :
- American journal of hematology. 67(2)
- Publication Year :
- 2001
-
Abstract
- The expression of p53, p21/WAF-1, Mdm2, c-Myc, and proliferating cell nuclear antigen (PCNA) proteins was examined by the immunohistochemistry of paraffin-embedded tissues of 62 patients with aggressive non-Hodgkin's lymphomas (NHL) and correlated to clinical data. Expression of p53, p21/WAF-1, Mdm2, and c-Myc protein was observed in 17 out of 62 cases (30%), 25 out of 60 (42%), 13 out of 44 (30%), and 39 out of 51 (76.5%), respectively. The p53+/p21WAF-1 phenotype, which is more frequently found in p53 mutations, was associated with a worse overall survival (P = 0.04) and with a lower rate of complete response (CR) (PF = 0.01). p53 and c-Myc negative expression was related to a better response to chemotherapy (PF = 0.005 and 0.035, respectively). The expression of p53, c-Myc, and Mdm2 was related to a shortened overall survival (P < 0.001, 0.05, and 0.037, respectively), suggesting that the expression of these proteins could be associated with a poor outcome in these patients.
- Subjects :
- Adult
Cyclin-Dependent Kinase Inhibitor p21
Male
Tumor suppressor gene
medicine.medical_treatment
Biology
Disease-Free Survival
Proto-Oncogene Proteins c-myc
Actuarial Analysis
Cyclins
Proliferating Cell Nuclear Antigen
Proto-Oncogene Proteins
Antineoplastic Combined Chemotherapy Protocols
medicine
Humans
Survival rate
Aged
Aged, 80 and over
Chemotherapy
Lymphoma, Non-Hodgkin
Nuclear Proteins
Proto-Oncogene Proteins c-mdm2
Hematology
Middle Aged
medicine.disease
Prognosis
Phenotype
Immunohistochemistry
Lymphoma
Non-Hodgkin's lymphoma
Proliferating cell nuclear antigen
Neoplasm Proteins
Survival Rate
Treatment Outcome
biology.protein
Cancer research
Female
Tumor Suppressor Protein p53
Subjects
Details
- ISSN :
- 03618609
- Volume :
- 67
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- American journal of hematology
- Accession number :
- edsair.doi.dedup.....c5e4367760fb729ce3430322103d6211