Back to Search
Start Over
Note of clarification of data in the paper entitled 'Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis'
- Source :
- Tumor Biology, Vol 39 (2017)
- Publication Year :
- 2017
- Publisher :
- IOS Press, 2017.
-
Abstract
- We read with great interest the paper entitled “Interferon gamma +874 T/A polymorphism increases the risk of cervical cancer: evidence from a meta-analysis” published online by Sun et al. Their results suggest that interferon gamma ( IFNG) gene +874 T/A polymorphism might contribute to women’s susceptibility to cervical cancer. They also found that IFNG +874 T/A polymorphism is associated with increased cervical cancer risk in Asian female population. The result is encouraging. Nevertheless, several key issues are worth noticing. We re-evaluate the association between IFNG +874 T/A polymorphism and cervical cancer risk by performing an updated meta-analysis based on 2777 cases and 2542 controls of 11 studies. We found that IFNG +874 T/A polymorphism was not significantly associated with cervical cancer risk in overall population. We also observed that the polymorphism was associated with enhanced cervical cancer risk in Asian population and was relevant to increased squamous cell cervical cancer risk.
- Subjects :
- Population
Uterine Cervical Neoplasms
Cervical intraepithelial neoplasia
Polymorphism, Single Nucleotide
03 medical and health sciences
Interferon-gamma
0302 clinical medicine
Asian People
medicine
Humans
Interferon gamma
Genetic Predisposition to Disease
education
RC254-282
Female population
Cervical cancer
education.field_of_study
030219 obstetrics & reproductive medicine
Polymorphism, Genetic
business.industry
Neoplasms. Tumors. Oncology. Including cancer and carcinogens
General Medicine
medicine.disease
030220 oncology & carcinogenesis
Meta-analysis
Immunology
Asian population
Female
business
Squamous cell cervical cancer
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 14230380
- Volume :
- 39
- Database :
- OpenAIRE
- Journal :
- Tumor Biology
- Accession number :
- edsair.doi.dedup.....c5e322f97d543acd55cb98d2b3654717