Back to Search
Start Over
Predictive performance of TPA testing for recurrent disease during follow-up after curative intent surgery for colorectal carcinoma
- Source :
- Clinical Chemistry and Laboratory Medicine, 55(2), 269-274. Walter de Gruyter GmbH, Clinical chemistry and laboratory medicine, 55(2), 269-274. Walter de Gruyter GmbH
- Publication Year :
- 2017
-
Abstract
- Background: The aim of the present study was to investigate the predictive performance of serial tissue polypeptide antigen (TPA) testing after curative intent resection for detection of recurrence of colorectal malignancy. Methods: Serum samples were obtained in 572 patients from three different hospitals during follow-up after surgery. Test characteristics of serial TPA testing were assessed using a cut-off value of 75 U/L. The relation with American Joint Committee on Cancer stage and the potential additive value of tissue polypeptide antigen testing upon standard carcinoembryonic antigen (CEA) testing were investigated. Results: The area under the receiver operating characteristic curve of TPA for recurrent disease was 0.70, indicating marginal usefulness as a predictive test. Forty percent of cases that were detected by CEA testing would have been missed by TPA testing alone, whilst most cases missed by CEA were also not detected by TPA testing. In the subpopulation of patients with stage III disease predictive performance was good (area under the curve 0.92 within 30 days of diagnosing recurrent disease). In this group of patients, 86% of cases that were detected by CEA were also detected by TPA. Conclusions: Overall, TPA is a relatively poor predictor for recurrent disease during follow-up. When looking at the specific subpopulation of patients with stage III disease predictive performance of TPA was good. However, TPA testing was not found to be superior to CEA testing in this specific subpopulation.
- Subjects :
- Male
Colorectal cancer
Tissue Polypeptide Antigen
Clinical Biochemistry
SDG 3 – Goede gezondheid en welzijn
TUMOR-MARKERS
Tissue Polypeptide Antigen/blood
0302 clinical medicine
Carcinoembryonic antigen
CEA
80 and over
Stage (cooking)
Predictive testing
Colorectal Neoplasms/blood
AMERICAN-SOCIETY
Aged, 80 and over
biology
integumentary system
Area under the curve
General Medicine
Middle Aged
tumor markers
030220 oncology & carcinogenesis
Adenocarcinoma
tissue polypeptide antigen
030211 gastroenterology & hepatology
Female
Colorectal Neoplasms
Adult
medicine.medical_specialty
RESECTION
colorectal cancer
DIAGNOSIS
03 medical and health sciences
SDG 3 - Good Health and Well-being
Neoplasm Recurrence, Local/blood
SURVEILLANCE
medicine
Humans
metastasis
CANCER PATIENTS
SERUM CARCINOEMBRYONIC ANTIGEN
Aged
Receiver operating characteristic
business.industry
Local/blood
carcinoembryonic antigen
Biochemistry (medical)
ADENOCARCINOMA
medicine.disease
Surgery
Neoplasm Recurrence
local neoplasm recurrence
biology.protein
PRACTICE GUIDELINE
Neoplasm Recurrence, Local
business
Subjects
Details
- Language :
- English
- ISSN :
- 14346621
- Volume :
- 55
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Clinical chemistry and laboratory medicine
- Accession number :
- edsair.doi.dedup.....c5e2b80dd3f4e44edce65844328fa0b1