Preparation of sol-gel organic-inorganic hybrid coatings for controlled drug release

The need to improve the tolerability and life time of the metallic implants, lead our research group to develop implantable therapeutic systems able to release an anti-inflammatory agent in the implant site. Therefore, in the present work, a sol-gel dip coating route has been optimized to coat titanium implant with two organic-inorganic hybrid materials: the first consisted of a glass zirconia matrix in which indomethacin (IND) was embedded, the second of a zirconia glass, the polyester poly (e-caprolactone) (PCL) and the IND. PCL was added into the materials to modulate the release kinetic of the IND. Moreover, coatings consisting of a different numbers of layers, were applied to a substrates to modulate the dosage of the released drug. The obtained coatings were characterized and the drug release was investigated as a function of the PCL content and of the layers’ number.The need to improve the tolerability and life time of the metallic implants, lead our research group to develop implantable therapeutic systems able to release an anti-inflammatory agent in the implant site. Therefore, in the present work, a sol-gel dip coating route has been optimized to coat titanium implant with two organic-inorganic hybrid materials: the first consisted of a glass zirconia matrix in which indomethacin (IND) was embedded, the second of a zirconia glass, the polyester poly (e-caprolactone) (PCL) and the IND. PCL was added into the materials to modulate the release kinetic of the IND. Moreover, coatings consisting of a different numbers of layers, were applied to a substrates to modulate the dosage of the released drug. The obtained coatings were characterized and the drug release was investigated as a function of the PCL content and of the layers’ number.