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Frailty as a phenotypic manifestation of underlying oxidative stress
- Source :
- Free Radical Biology and Medicine. 149:72-77
- Publication Year :
- 2020
- Publisher :
- Elsevier BV, 2020.
-
Abstract
- Oxidative stress plays a key role in the aging process. Lifestyle behaviours including low physical activity and inadequate nutritional habits in addition to genetic susceptibility and some chronic diseases compromise physiological response to free radicals and promote oxidative damage. Reduced resilience (referred to the ability to respond to stressors or adverse conditions) or functional reserve in isolated organs or systems determines clinical manifestations as the age-related chronic diseases while multisystemic dysfunction results in the frailty phenotype. In older adults, frailty, but not age, is associated with elevation of oxidative stress markers and reduction of antioxidant parameters. Mitochondrial dysfunction related to oxidative stress plays a prominent role in this process affecting not only skeletal muscle but also other potential tissues and organs. Increasing endogenous antioxidant capacity in different systems by exercise outstand among therapeutic interventions with potential ability to prevent or delay frailty phenotype and to promote healthy aging.
- Subjects :
- 0301 basic medicine
Antioxidant
Free Radicals
medicine.medical_treatment
Bioinformatics
medicine.disease_cause
Biochemistry
Antioxidants
03 medical and health sciences
0302 clinical medicine
Physiology (medical)
Genetic predisposition
Humans
Medicine
Healthy aging
Aged
Frailty
business.industry
Adverse conditions
Stressor
Skeletal muscle
Phenotype
Oxidative Stress
030104 developmental biology
medicine.anatomical_structure
business
030217 neurology & neurosurgery
Oxidative stress
Subjects
Details
- ISSN :
- 08915849
- Volume :
- 149
- Database :
- OpenAIRE
- Journal :
- Free Radical Biology and Medicine
- Accession number :
- edsair.doi.dedup.....c5b37930d2a91864039529262dfd18d5