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Role of Pharmacogenomics in Antiepileptic Drug Therapy: Current Status and Future Perspectives
- Source :
- Current Pharmaceutical Design. 23:5760-5765
- Publication Year :
- 2018
- Publisher :
- Bentham Science Publishers Ltd., 2018.
-
Abstract
- BACKGROUND Growing evidence indicates that pharmacogenomics will positively impact treatment for patients with epilepsy in the near future, leading to the implementation of a precision-based use of antiepileptic drug (AED) therapy, thereby providing a cornerstone for precision medicine. OBJECTIVE In this review, we briefly summarize the studies of pharmacogenomics in epilepsy, recent advances, and how it may progress in the future. METHODS We subdivided the review into two main sections: genetic variants that may modulate response to AEDs through pharmacokinetics or pharmacodynamics mechanisms; and gene variants that may affect tolerability and safety of AEDs. RESULTS Results from most studies have been contradictory, due to several flaws, including small sample sizes, inaccurate phenotyping, and genotyping strategies. However, even with these limitations, very recent developments indicate that the goal of incorporating genetic data into clinical practice may be attainable in the near future. In addition, recent pharmacogenomic studies of hypersensitivity reactions to AEDs have also made important strides, as its prevention appears attainable with the identification of HLA-A genotypes for patients at high risk of carbamazepine hypersensitivity. CONCLUSION To better clarify the relationship between genetic factors and AEDs, future studies will require more precise epilepsy phenotypes, larger sample sizes, and astute use of new genotyping strategies. Reasonably, this will lead to novel therapeutic approaches in drug targeting and antiepileptogenesis.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Future studies
Antiepileptic drug
Pharmacology
03 medical and health sciences
Epilepsy
0302 clinical medicine
Drug Discovery
medicine
Humans
Precision Medicine
Intensive care medicine
business.industry
Small sample
medicine.disease
Precision medicine
Phenotype
030104 developmental biology
Tolerability
Targeted drug delivery
Pharmacogenetics
Pharmacogenomics
Anticonvulsants
business
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 13816128
- Volume :
- 23
- Database :
- OpenAIRE
- Journal :
- Current Pharmaceutical Design
- Accession number :
- edsair.doi.dedup.....c5ad87351163cdc85b2ba0c70287cdef