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New hypotheses for cancer generation and progression
- Source :
- Medical Hypotheses. 152:110614
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Since Nixon famously declared war on cancer in 1971, trillions of dollars have been spent on cancer research but the life expectancy for most forms of cancer is still poor. There are many reasons for the partial success of cancer translational research. One of these can be the predominance of certain paradigms that potentially narrowed the vision in interpreting cancer. The main paradigm to explain carcinogenesis is based on DNA mutations, which is well interpreted by the somatic mutation theory (SMT). However, a different theory claims that cancer is instead a tissue disease as proposed by the Tissue Organization Field Theory (TOFT). Here, we propose new hypotheses to explain the origin and pathogenesis of cancer. In this perspective, the systemic-evolutionary theory of cancer (SETOC) is discussed as well as how the microenvironment affects the adaptation of transformed cells and the reversion to a unicellular-like or embryo-like phenotype.
- Subjects :
- 0301 basic medicine
Carcinogenesis
Translational research
Disease
medicine.disease_cause
03 medical and health sciences
0302 clinical medicine
Germline mutation
Neoplasms
Tumor Microenvironment
medicine
Humans
Cognitive science
Cancer
General Medicine
medicine.disease
Biological Evolution
Cell Cannibalism
Dna mutation
Phenotype
030104 developmental biology
Mutation
Life expectancy
Psychology
030217 neurology & neurosurgery
Subjects
Details
- ISSN :
- 03069877
- Volume :
- 152
- Database :
- OpenAIRE
- Journal :
- Medical Hypotheses
- Accession number :
- edsair.doi.dedup.....c5aae6a6b52b803631a832222fa2dcd9