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Urine miRNAs as potential biomarkers for systemic reactions induced by exposure to embedded metal
- Source :
- Biomarkers in medicine. 15(15)
- Publication Year :
- 2021
-
Abstract
- Aim: Explore the potential of urine microRNAs as biomarkers that may reflect the biological responses to pure metals embedded in skeletal muscle over time. Materials & methods: We tested a panel of military-relevant metals embedded in the gastrocnemius muscles of 3-month-old, male, Sprague–Dawley rats (n = 8/group) for a duration of 1, 3, 6 and 12 months, and performed small RNA-sequencing on the urine samples. Results: Results provide potential tissue targets affected by metal exposure and a list of unique or common urine microRNA biomarkers indicative of exposure to various metals, highlighting a complex systemic response. Conclusion: We have identified a panel of miRNAs as potential urine biomarkers to reflect the complex systemic response to embedded metal exposure.
- Subjects :
- Male
Clinical Biochemistry
Urine
Pharmacology
Mass Spectrometry
Rats, Sprague-Dawley
Drug Discovery
microRNA
medicine
Animals
Humans
RNA-Seq
Military Medicine
Muscle, Skeletal
Veterans
business.industry
Pure metals
Gene Expression Profiling
Biochemistry (medical)
Skeletal muscle
Systemic reaction
MicroRNAs
medicine.anatomical_structure
Urine biomarkers
Gene Expression Regulation
Metals
Potential biomarkers
Models, Animal
business
Biomarkers
Subjects
Details
- ISSN :
- 17520371
- Volume :
- 15
- Issue :
- 15
- Database :
- OpenAIRE
- Journal :
- Biomarkers in medicine
- Accession number :
- edsair.doi.dedup.....c59feba95846c5a6f191913761ce4cce