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Spinal cord stimulation suppresses focal rapid firing-induced atrial fibrillation by inhibiting atrial ganglionated plexus activity
- Source :
- Journal of cardiovascular pharmacology. 64(6)
- Publication Year :
- 2014
-
Abstract
- OBJECTIVE This study was designed to demonstrate that spinal cord stimulation (SCS) could suppress high-frequency stimulation (HFS)-induced focal atrial fibrillation (AF) at atrial and pulmonary vein (PV) sites by inhibiting atrial ganglionated plexus (GP) activity. METHODS Multielectrode catheters were attached to atria and all PV sites. SCS was performed at the T1-T5 spinal region for 1 hour. At the baseline state and the end of 1 hour of SCS, 40 milliseconds of HFS was delivered 2 milliseconds after atrial pacing to determine the AF threshold at each site. One electrode was attached to the superior left GP so that HFS to this site induced sinus rate slowing. Microelectrodes inserted into the anterior right GP recorded neural firing. RESULTS SCS induced a significant increase in AF threshold at all sites (all P < 0.05). The sinus rate slowing response induced by superior left GP stimulation was blunted by SCS (17% ± 3.6% vs. 39% ± 3.8%, P < 0.05). The frequency (32 ± 4 vs. 87 ± 6 impulses per minute, P < 0.05) and amplitude (0.16 ± 0.02 vs. 0.42 ± 0.04 mv, P < 0.05) of the neural activity recorded from the anterior right GP were markedly inhibited by SCS. CONCLUSIONS SCS may prevent episodic AF caused by rapid PV and non-PV firing through modulating GP activity.
- Subjects :
- Male
medicine.medical_specialty
Stimulation
Spinal cord stimulation
Pulmonary vein
Neural activity
Dogs
Anterior right
Internal medicine
Atrial Fibrillation
medicine
Animals
Ganglionated plexus
Heart Atria
Ganglia, Autonomic
Pharmacology
Spinal Cord Stimulation
integumentary system
Atrial pacing
business.industry
Atrial fibrillation
medicine.disease
Disease Models, Animal
nervous system
Pulmonary Veins
Anesthesia
Cardiology
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- ISSN :
- 15334023
- Volume :
- 64
- Issue :
- 6
- Database :
- OpenAIRE
- Journal :
- Journal of cardiovascular pharmacology
- Accession number :
- edsair.doi.dedup.....c59db05ba580fdf4cf027454777c36cb