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Diabetes Mellitus and Obesity as Risk Factors for Pancreatic Cancer
- Source :
- Journal of the Academy of Nutrition and Dietetics. 118:555-567
- Publication Year :
- 2018
- Publisher :
- Elsevier BV, 2018.
-
Abstract
- Pancreatic ductal adenocarcinoma (PDAC) is among the deadliest types of cancer. The worldwide estimates of its incidence and mortality in the general population are eight cases per 100,000 person-years and seven deaths per 100,000 person-years, and they are significantly higher in the United States than in the rest of the world. The incidence of this disease in the United States is more than 50,000 new cases in 2017. Indeed, total deaths due to PDAC are projected to increase dramatically to become the second leading cause of cancer-related deaths before 2030. Considering the failure to date to efficiently treat existing PDAC, increased effort should be undertaken to prevent this disease. A better understanding of the risk factors leading to PDAC development is of utmost importance to identify and formulate preventive strategies. Large epidemiologic and cohort studies have identified risk factors for the development of PDAC, including obesity and type 2 diabetes mellitus. This review highlights the current knowledge of obesity and type 2 diabetes as risk factors for PDAC development and progression, their interplay and underlying mechanisms, and the relation to diet. Research gaps and opportunities to address this deadly disease are also outlined.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
endocrine system diseases
Population
Type 2 diabetes
Disease
Article
03 medical and health sciences
0302 clinical medicine
Risk Factors
Pancreatic cancer
Diabetes mellitus
medicine
Humans
Obesity
Intensive care medicine
education
education.field_of_study
Nutrition and Dietetics
business.industry
Incidence
Incidence (epidemiology)
Type 2 Diabetes Mellitus
General Medicine
medicine.disease
United States
digestive system diseases
Surgery
Pancreatic Neoplasms
030104 developmental biology
Diabetes Mellitus, Type 2
030220 oncology & carcinogenesis
business
Carcinoma, Pancreatic Ductal
Food Science
Cohort study
Subjects
Details
- ISSN :
- 22122672
- Volume :
- 118
- Database :
- OpenAIRE
- Journal :
- Journal of the Academy of Nutrition and Dietetics
- Accession number :
- edsair.doi.dedup.....c598710a429ce2c71a3182df98a9620d