Back to Search
Start Over
Gene network analyses unveil possible molecular basis underlying drug-induced glaucoma
- Source :
- BMC Medical Genomics, Vol 14, Iss 1, Pp 1-11 (2021), BMC Medical Genomics
- Publication Year :
- 2021
- Publisher :
- BMC, 2021.
-
Abstract
- Background Drug-induced glaucoma (DIG) is a kind of serious adverse drug reaction that can cause irreversible blindness. Up-to-date, the molecular mechanism of DIG largely remains unclear yet due to the medical complexity of glaucoma onset. Methods In this study, we conducted data mining of tremendous historical adverse drug events and genome-wide drug-regulated gene signatures to identify glaucoma-associated drugs. Upon these drugs, we carried out serial network analyses, including the weighted gene co-expression network analysis (WGCNA), to illustrate the gene interaction network underlying DIG. Furthermore, we applied pathogenic risk assessment to discover potential biomarker genes for DIG. Results As the results, we discovered 13 highly glaucoma-associated drugs, a glaucoma-related gene network, and 55 glaucoma-susceptible genes. These genes likely played central roles in triggering DIGs via an integrative mechanism of phototransduction dysfunction, intracellular calcium homeostasis disruption, and retinal ganglion cell death. Further pathogenic risk analysis manifested that a panel of nine genes, particularly OTOF gene, could serve as potential biomarkers for early-onset DIG prognosis. Conclusions This study elucidates the possible molecular basis underlying DIGs systematically for the first time. It also provides prognosis clues for early-onset glaucoma and thus assists in designing better therapeutic regimens.
- Subjects :
- 0301 basic medicine
Drug-induced glaucoma
genetic structures
Gene regulatory network
Adverse drug reaction
Computational biology
Biology
QH426-470
03 medical and health sciences
0302 clinical medicine
Dig
The weighted gene co-expression network analysis
medicine
OTOF
Genetics
Gene
Internal medicine
Genetics (clinical)
Mechanism (biology)
Research
medicine.disease
RC31-1245
Human genetics
eye diseases
Glaucoma biomarkers
030104 developmental biology
030221 ophthalmology & optometry
sense organs
DNA microarray
Glaucoma, Open-Angle
Subjects
Details
- Language :
- English
- ISSN :
- 17558794
- Volume :
- 14
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC Medical Genomics
- Accession number :
- edsair.doi.dedup.....c57d7bde2423d7e902820dc55815e30a