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Meningeal seeding from glioblastoma multiforme treated with radiotherapy and temozolomide
- Source :
- Asian Journal of Surgery, Vol 40, Iss 1, Pp 61-65 (2017), Scipedia Open Access, Scipedia SL
- Publisher :
- Asian Surgical Association. Published by Elsevier Taiwan LLC.
-
Abstract
- SummaryExtracranial and meningeal seeding of glioblastoma multiforme is rare. We report herein a case of glioblastoma in a 41-year-old man who underwent surgical resection, concomitant chemoradiotherapy (CCRT) and seven courses of adjuvant chemotherapy with temozolomide. The patient then complained of intermittent severe lower back pain and gait disturbance. Imaging studies demonstrated that although the intracranial residual tumors were well-controlled by the treatment, meningeal seeding involving the brainstem and spinal cord was present. The patient died 2 months after the diagnosis of spinal seeding. This case illustrates the need for consideration of extracranial metastasis if a patient is symptomatic, even if the intracranial tumor appears responsive to treatment. We suggested that the prophylactic craniospinal irradiation may be considered in patients at high risk of meningeal seeding immediately after surgery.
- Subjects :
- Adult
Male
medicine.medical_specialty
medicine.medical_treatment
spinal
lcsh:Surgery
temozolomide
Craniospinal Irradiation
03 medical and health sciences
glioblastoma multiforme
0302 clinical medicine
Fatal Outcome
Neoplasm Seeding
medicine
Back pain
Meningeal Neoplasms
Humans
Antineoplastic Agents, Alkylating
meningeal seeding
Extracranial metastasis
Temozolomide
business.industry
Brain Neoplasms
lcsh:RD1-811
Chemoradiotherapy, Adjuvant
medicine.disease
Spinal cord
Surgery
Radiation therapy
Dacarbazine
medicine.anatomical_structure
030220 oncology & carcinogenesis
Seeding
medicine.symptom
business
Glioblastoma
030217 neurology & neurosurgery
medicine.drug
Subjects
Details
- Language :
- English
- ISSN :
- 10159584
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Asian Journal of Surgery
- Accession number :
- edsair.doi.dedup.....c57d60b12308af66833d069e302692c1
- Full Text :
- https://doi.org/10.1016/j.asjsur.2013.07.012