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Characterization of immune responses elicited in mice by intranasal co-immunization with HIV-1 Tat, gp140 DeltaV2Env and/or SIV Gag proteins and the nontoxicogenic heat-labile Escherichia coli enterotoxin
- Source :
- Vaccine. 26(9)
- Publication Year :
- 2007
-
Abstract
- The development of a vaccine against HIV/AIDS capable of inducing broad humoral and cellular responses at both systemic and mucosal sites, able to stop or reduce viral infection at the portal of entry, represents the only realistic way to control the infection caused by HIV world-wide. The promising results obtained with the HIV-1 Tat-based vaccines in preclinical and clinical settings, the evidence that a broad immunity against HIV correlates with reduced viral load or virus control, as well as the availability of novel gp140 V2-loop deleted HIV-1 Env (DeltaV2Env) immunogens capable of inducing cross-reactive neutralizing antibodies, have led to the design of new vaccine strategies based on the combination of non-structural and structural proteins. In this study, we demonstrate that immunization with a biologically active HIV-1 Tat protein in combination with the oligomeric HIV-1 gp140 DeltaV2Env and/or SIV Gag proteins, delivered intranasally with the detoxified LTK63 mucosal adjuvant, whose safety has been recently shown in humans, elicits long-lasting local and systemic antibody and cellular immune responses against the co-administered antigens in a fashion similar to immune responses induced by vaccination with Tat, DeltaV2Env and Gag proteins alone. The results indicate lack of antigen interference implying that HIV-1 Tat is an optimal co-antigen for combined vaccine strategies employing DeltaV2Env and/or Gag proteins.
- Subjects :
- T-Lymphocytes
Bacterial Toxins
Gene Products, gag
HIV Infections
HIV Antibodies
Enterotoxins
Mice
Immune system
Antigen
Adjuvants, Immunologic
Immunity
Animals
Humans
Immunity, Mucosal
Administration, Intranasal
Glycoproteins
AIDS Vaccines
Mice, Inbred BALB C
General Veterinary
General Immunology and Microbiology
biology
Escherichia coli Proteins
Vaccination
Public Health, Environmental and Occupational Health
biology.organism_classification
Virology
Infectious Diseases
Immunization
Lentivirus
Immunology
Gene Products, tat
biology.protein
HIV-1
Molecular Medicine
Female
Simian Immunodeficiency Virus
Antibody
Viral load
Subjects
Details
- ISSN :
- 0264410X
- Volume :
- 26
- Issue :
- 9
- Database :
- OpenAIRE
- Journal :
- Vaccine
- Accession number :
- edsair.doi.dedup.....c574cfcc42a0d360b2067142d17512f4