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A ubiquitous disordered protein interaction module orchestrates transcription elongation
- Source :
- Science
- Publication Year :
- 2021
-
Abstract
- Organized by unstructured motifs The high degree of conservation in protein sequences thought to be unstructured has hinted that these regions may have important biological functions. Although unstructured regions are widely viewed to be crucial for protein signaling, localization, and stability, their roles in many other settings have remained mysterious. Cermakova et al . discovered that prominent members of the transcription elongation machinery are linked through a network of interactions involving transcription elongation factor TFIIS N-terminal domains (TNDs) and conserved unstructured sequences called “TND-interacting motifs” (TIMs). The researchers found that mutation of a single TIM in a central organizing protein of this network abolished key protein interactions and induced widespread defects in transcription elongation dynamics. —DJ
- Subjects :
- Models, Molecular
Transcription Elongation, Genetic
Transcription elongation
Gene Expression
RNA polymerase II
Article
Protein Domains
Cell Line, Tumor
Humans
Protein Interaction Domains and Motifs
Protein Interaction Maps
Adaptor Proteins, Signal Transducing
Multidisciplinary
biology
Chemistry
Eukaryotic transcription
RNA-Binding Proteins
Cell biology
DNA-Binding Proteins
Intrinsically Disordered Proteins
Mutation
biology.protein
RNA Polymerase II
Elongation
Transcriptional Elongation Factors
Protein Binding
Transcription Factors
Subjects
Details
- Language :
- English
- Database :
- OpenAIRE
- Journal :
- Science
- Accession number :
- edsair.doi.dedup.....c568e193dc8dcfef56eca62617fab1ae