New platinum complexes with anti-tumour activity

The effects of cis-dichlorodiammineplatinum(II) on experimental tumours and its preliminary trials in man has led to the search for related compounds with anti-tumour activity. A number of platinum complexes have been prepared and tested for their ability to cause regression of a mouse plasma cell tumour. A class of compounds have been found which are some thirty to forty times more active against the plasma cell tumour than the platinum complex at present on clinical trial.