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Diagnostic and Therapeutic Potential of Exosomal MicroRNAs for Neurodegenerative Diseases
- Source :
- Neural Plasticity, Vol 2021 (2021), Neural Plasticity
- Publication Year :
- 2021
- Publisher :
- Hindawi Limited, 2021.
-
Abstract
- Neurodegenerative disorders (NDs) are characterized by a gradual loss of neurons and functions that eventually leads to progressive neurological impairment. In view of the heavy burden on the healthcare system, efficient and reliable biomarkers for early diagnosis and therapeutic treatments to reverse the progression of NDs are in urgent need. There has been an increasing interest in using exosomal miRNAs as biomarkers or targeted therapies for neurological diseases recently. In this review, we overviewed the updated studies on exosomal miRNAs as biomarkers and potential therapeutic approaches in NDs, as well as their association with the pathophysiology of this group of disorders, especially Alzheimer’s disease (AD), Parkinson’s disease (PD), amyotrophic lateral sclerosis (ALS), and Huntington’s disease (HD). The exosomal miRNAs that are commonly dysregulated across different NDs or are commonly used as therapeutic candidates were also identified and summarized. In summary, the feasibility of exosomal miRNAs as biomarkers and potential targeted therapy for NDs has been verified. However, due to the limitations of existing studies and the discrepancies across different studies, high quality laboratory and clinical investigations are still required.
- Subjects :
- medicine.medical_treatment
Neurosciences. Biological psychiatry. Neuropsychiatry
Review Article
Disease
Bioinformatics
Targeted therapy
03 medical and health sciences
0302 clinical medicine
microRNA
medicine
Animals
Humans
Exosomal mirnas
Amyotrophic lateral sclerosis
030304 developmental biology
0303 health sciences
business.industry
Neurodegenerative Diseases
Genetic Therapy
medicine.disease
MicroRNAs
Neurology
Neurology (clinical)
business
Neurological impairment
Biomarkers
030217 neurology & neurosurgery
RC321-571
Healthcare system
Subjects
Details
- ISSN :
- 16875443 and 20905904
- Volume :
- 2021
- Database :
- OpenAIRE
- Journal :
- Neural Plasticity
- Accession number :
- edsair.doi.dedup.....c566967c8241e9f7cceedd7031f4b5a8