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Constituents of SH1, a novel lipid-containing virus infecting the halophilic euryarchaeon Haloarcula hispanica
- Source :
- Journal of virology. 79(14)
- Publication Year :
- 2005
-
Abstract
- Recent studies have indicated that a number of bacterial and eukaryotic viruses that share a common architectural principle are related, leading to the proposal of an early common ancestor. A prediction of this model would be the discovery of similar viruses that infect archaeal hosts. Our main interest lies in icosahedral double-stranded DNA (dsDNA) viruses with an internal membrane, and we now extend our studies to include viruses infecting archaeal hosts. While the number of sequenced archaeal viruses is increasing, very little sequence similarity has been detected between bacterial and eukaryotic viruses. In this investigation we rigorously show that SH1, an icosahedral dsDNA virus infecting Haloarcula hispanica , possesses lipid structural components that are selectively acquired from the host pool. We also determined the sequence of the 31-kb SH1 genome and positively identified genes for 11 structural proteins, with putative identification of three additional proteins. The SH1 genome is unique and, except for a few open reading frames, shows no detectable similarity to other published sequences, but the overall structure of the SH1 virion and its linear genome with inverted terminal repeats is reminiscent of lipid-containing dsDNA bacteriophages like PRD1.
- Subjects :
- Immunology
Molecular Sequence Data
Genome, Viral
Microbiology
Genome
Virus
03 medical and health sciences
chemistry.chemical_compound
Open Reading Frames
Virology
Bacteriophage PRD1
Amino Acid Sequence
Gene
Peptide sequence
030304 developmental biology
Genetics
Viral Structural Proteins
0303 health sciences
Haloarcula
biology
030306 microbiology
Archaeal Viruses
biology.organism_classification
Lipids
Open reading frame
chemistry
Genetic Diversity and Evolution
Insect Science
Capsid Proteins
DNA
Subjects
Details
- ISSN :
- 0022538X
- Volume :
- 79
- Issue :
- 14
- Database :
- OpenAIRE
- Journal :
- Journal of virology
- Accession number :
- edsair.doi.dedup.....c54bdd265a64999c15844e535c8cbf5f