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PPARδ Promotes Running Endurance by Preserving Glucose
- Source :
- Cell metabolism. 25(5)
- Publication Year :
- 2016
-
Abstract
- Management of energy stores is critical during endurance exercise, with a shift in substrate utilization from glucose towards fat being a hallmark of trained muscle. Here we show that this key metabolic adaptation is both dependent on muscle PPARδ and stimulated by PPARδ ligand. Furthermore, we find that muscle PPARδ expression positively correlates with endurance performance in BXD mouse reference populations. In addition to stimulating fatty acid metabolism in sedentary mice, PPARδ activation potently suppresses glucose catabolism and does so without affecting either muscle fiber type or mitochondrial content. By preserving systemic glucose levels PPARδ acts to delay the onset of hypoglycemia and extends running time by ~100 minutes in treated mice. Collectively, these results identify a bifurcated PPARδ program that underlies glucose sparing and highlight the potential of PPARδ-targeted exercise mimetics in the treatment of metabolic disease, dystrophies and unavoidably, the enhancement of athletic performance.
- Subjects :
- 0301 basic medicine
Male
medicine.medical_specialty
Physiology
Hypoglycemia
Biology
Carbohydrate metabolism
Article
Cell Line
Running
Myoblasts
03 medical and health sciences
chemistry.chemical_compound
Mice
Endurance training
Internal medicine
Physical Conditioning, Animal
medicine
Myocyte
Animals
PPAR delta
Metabolic disease
Muscle, Skeletal
Molecular Biology
Fatty acid metabolism
Fatty Acids
Cell Biology
medicine.disease
Running time
Mitochondria, Muscle
030104 developmental biology
Endocrinology
Glucose
chemistry
Physical Endurance
Peroxisome proliferator-activated receptor delta
Subjects
Details
- ISSN :
- 19327420
- Volume :
- 25
- Issue :
- 5
- Database :
- OpenAIRE
- Journal :
- Cell metabolism
- Accession number :
- edsair.doi.dedup.....c547cabc4ab494e28f77b85f215da128