Syntheses of fluorooxindole and 2-fluoro-2-arylacetic acid derivatives from diethyl 2-fluoromalonate ester

Authors :: Antal Harsanyi
Graham Sandford
Judith A. K. Howard
Dmitri S. Yufit
Source :: Beilstein Journal of Organic Chemistry, Vol 10, Iss 1, Pp 1213-1219 (2014), Beilstein journal of organic chemistry, 2014, Vol.10, pp.1213-1219 [Peer Reviewed Journal], Beilstein Journal of Organic Chemistry
Publication Year :: 2014
Publisher :: Beilstein-Institut, 2014.
Abstract: Diethyl 2-fluoromalonate ester is utilised as a building block for the synthesis of 2-fluoro-2-arylacetic acid and fluorooxindole derivatives by a strategy involving nucleophilic aromatic substitution reactions with ortho-fluoronitrobenzene substrates followed by decarboxylation, esterification and reductive cyclisation processes.

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