Composite Dynamic Hydrogels Constructed on Boronic Ester Cross-Links with NIR-Enhanced Diffusivity

Dynamic hydrogels with thermosensitive cross-links are highly promising platforms for "on-demand" drug delivery systems. However, there is a problem with triggering a response in their whole volume, which reduces their efficiency. To achieve better thermoresponsiveness, a graphene oxide-filled composite hydrogel based on boronic ester cross-links, composed of hyperbranched polyglycidol, HbPGL, and poly(acrylamide-ran-2-acrylamidephenylboronic acid), poly(AM-ran-2-AAPBA), has been constructed. The homogeneous embedment of graphene oxide (GO) in the network assured near-infrared (NIR)-photothermal response in its bulk due to the rapid light-to-heat conversion. The rate and amplitude of materials response increase with graphene oxide concentration. The temperature of the hydrogel containing graphene oxide at a concentration of 13.2 mg/mL increased from 36.6 to 41 °C in 29 s upon NIR irradiation. The network diffusivity and the extent of its change with temperature can be regulated by the length of the applied boronic acid-based cross-linking agent. The hydrogel constructed on the shorter copolymer (