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Multilocus Variable-Number Tandem-Repeat Analysis-Confirmed Emergence of a Macrolide Resistance-Associated Mutation in Mycoplasma pneumoniae during Macrolide Therapy for Interstitial Pneumonia in an Immunocompromised Child

Authors :
Olivia Peuchant
A. Charron
Céline Menetrey
Sébastien Hantz
Marie-Cécile Ploy
Fabien Garnier
Cécile Bébéar
Sabine Pereyre
Anti-infectieux : supports moléculaires des résistances et innovations thérapeutiques (RESINFIT)
Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST)
Université de Limoges (UNILIM)-Université de Limoges (UNILIM)-CHU Limoges
Service de Bactériologie, Virologie, Hygiène [CHU Limoges]
CHU Limoges
Laboratoire de Bactériologie
CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin
Université Bordeaux Segalen - Bordeaux 2
Service de Pédiatrie médicale [CHU Limoges]
Centre d'Investigation Clinique de Limoges (CIC1435)
Institut National de la Santé et de la Recherche Médicale (INSERM)-CHU Limoges
Service de Bactériologie
Hôpital Pellegrin-Tripode
Douady, Claire
CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Génomique, Environnement, Immunité, Santé, Thérapeutique (GEIST)
Université de Limoges (UNILIM)-Université de Limoges (UNILIM)
CHU Limoges-Institut National de la Santé et de la Recherche Médicale (INSERM)
Source :
Journal of Clinical Microbiology, Journal of Clinical Microbiology, American Society for Microbiology, 2012, 50 (10), pp.3402-3405. ⟨10.1128/JCM.01248-12⟩
Publication Year :
2012
Publisher :
HAL CCSD, 2012.

Abstract

A child with Job's syndrome was treated for pneumonia due to Mycoplasma pneumoniae . A mixed population of wild-type bacteria and an A2059G mutant was detected during josamycin treatment failure. The same multilocus variable-number tandem-repeat analysis (MLVA) type (MLVA type I) was isolated before and after treatment failure. The child recovered after ciprofloxacin treatment.

Subjects

Subjects :
Microbiology (medical)
Male
Mycoplasma pneumoniae
Josamycin
Population
Drug resistance
Case Reports
Minisatellite Repeats
Multiple Loci VNTR Analysis
Biology
medicine.disease_cause
Microbiology
03 medical and health sciences
Ciprofloxacin
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Drug Resistance, Bacterial
Pneumonia, Mycoplasma
medicine
Humans
pneumonia
Treatment Failure
education
Child
030304 developmental biology
Salvage Therapy
0303 health sciences
education.field_of_study
030306 microbiology
MLVA
medicine.disease
bacterial infections and mycoses
Virology
[SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
3. Good health
Anti-Bacterial Agents
Mycoplasma pneumoniae infection
Variable number tandem repeat
Pneumonia
Mutation
[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Macrolides
[SDV.MP.BAC] Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology
Lung Diseases, Interstitial
medicine.drug

Details

Language :
English
ISSN :
00951137
Database :
OpenAIRE
Journal :
Journal of Clinical Microbiology, Journal of Clinical Microbiology, American Society for Microbiology, 2012, 50 (10), pp.3402-3405. ⟨10.1128/JCM.01248-12⟩
Accession number :
edsair.doi.dedup.....c52f3f82c8f72d605e94cd2dd8ec4b9d
Full Text :
https://doi.org/10.1128/JCM.01248-12⟩
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