А Method and a Device for Evaluating the Functional State of Microcirculatory-Tissue Systems of the Human Body Based on Multiparametric Optical Diagnostics

Introduction. Violations of the microcirculatory-tissue systems of the human body play a key role in the pathogenesis of various diseases complications. However, there are a few unresolved methodological and instrumental problems with non-invasive monitoring of microcirculatory function and metabolic disorders associated with insufficient accuracy, reproducibility and informativeness of diagnostic results. The proposed approach of multiparametric optical diagnostics, when optical non-invasive technologies are used in combination, can be a promising tool that improves the sensitivity and accuracy of detecting microcirculatory and metabolic disorders at an early stage, which is important for the diagnosis and treatment of diseases of various profiles.Aim. Development of a method and device for assessing the functional state of microcirculatory-tissue systems of the human body based on multiparametric optical diagnostics and assessment of its diagnostic potential in clinical practice.Materials and methods. In the paper, theories of radiation transfer, applied mathematical statistics and clinical research methods are used. The statistical indicators of the developed diagnostic methods are given, the principle of the device construction is described.Results. An original method and principle for constructing a device for assessing the functional state of microcirculatory-tissue systems of the human body based on multiparametric optical diagnostics has been developed.Conclusion. The present work presents a method and device for assessing the functional state of microcirculatory-tissue systems of the human body based on this approach. The basic principles of each of the diagnostic channels (laser Doppler flowmetry, fluorescence spectroscopy and diffuse reflectance spectroscopy) are described. Examples of the clinical application of the described device in various fields of medicine (endocrinology, rheumatology, minimally invasive surgery) are presented. The method proposed in this article and principle for constructing a device with the possibility of its technical adaptation by developing additional probes for specific tasks of biomedical research makes optical non-invasive diagnostics affordable and increases its information content.