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Synthesis of Eudragit® L100-coated chitosan-based nanoparticles for oral enoxaparin delivery
- Source :
- International Journal of Biological Macromolecules. 193:450-456
- Publication Year :
- 2021
- Publisher :
- Elsevier BV, 2021.
-
Abstract
- Enoxaparin is an effective biological molecule for prevention and treatment of coagulation disorders. However, it is poorly absorbed in the gastrointestinal tract. In this study, we developed an Eudragit® L100 coated chitosan core shell nanoparticles for enoxaparin oral delivery (Eud/CS/Enox NPs) through a completely eco-friendly method without employing any high-energy homogenizer technique and any organic solvents. Spherical nanocarriers were successfully prepared with particle size lower than 300 nm, polydispersity index about 0.12 and zeta potential higher than +25 mV, entrapment efficiency greater than 95% and the in vitro release behavior confirms the good colloidal stability and the successful Eudragit® L100 coating process demonstrated by negligible cumulative enoxaparin release (
Details
- ISSN :
- 01418130
- Volume :
- 193
- Database :
- OpenAIRE
- Journal :
- International Journal of Biological Macromolecules
- Accession number :
- edsair.doi.dedup.....c503e9d4d8340fcdcd485533bbe7fef0