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Noncoding RNAs in pediatric brain tumors: Molecular functions and pathological implications

Authors :
Hansong Sheng
Xiangyang Deng
Yuxi Rong
Jian Lin
Yanhao Zheng
Shaohuai Chen
Yusong Zhang
Source :
Molecular Therapy. Nucleic Acids, Molecular Therapy: Nucleic Acids, Vol 26, Iss, Pp 417-431 (2021)
Publication Year :
2021
Publisher :
Elsevier BV, 2021.

Abstract

Brain tumors are common solid pediatric malignancies and the main reason for cancer-related death in the pediatric setting. Recently, evidence has revealed that noncoding RNAs (ncRNAs), including microRNAs (miRNAs), long ncRNAs (lncRNAs), and circular RNAs (circRNAs), play a critical role in brain tumor development and progression. Therefore, in this review article, we describe the functions and molecular mechanisms of ncRNAs in multiple types of cancer, including medulloblastoma, pilocytic astrocytoma, ependymoma, atypical teratoid/rhabdoid tumor, glioblastoma, diffuse intrinsic pontine glioma, and craniopharyngioma. We also mention the limitations of using ncRNAs as therapeutic targets because of the nonspecificity of ncRNA targets and the delivery methods of ncRNAs. Due to the critical role of ncRNAs in brain oncogenesis, targeting aberrantly expressed ncRNAs might be an effective strategy to improve the outcomes of pediatric patients with brain tumors.<br />Graphical abstract<br />In this review article, the authors describe the functions and molecular mechanisms of ncRNAs, such as miRNAs, lncRNAs, and circRNAs, in pediatric brain malignancies, including medulloblastoma, pilocytic astrocytoma, ependymoma, atypical teratoid/rhabdoid tumor, glioblastoma, diffuse intrinsic pontine glioma, and craniopharyngioma.

Details

ISSN :
21622531
Volume :
26
Database :
OpenAIRE
Journal :
Molecular Therapy - Nucleic Acids
Accession number :
edsair.doi.dedup.....c5009444e207b4da33b4c6b172b1eaf3