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The long view: a selective review of 40 years of Newcastle disease research
- Source :
- Avian Pathology. 41:329-335
- Publication Year :
- 2012
- Publisher :
- Informa UK Limited, 2012.
-
Abstract
- This review is written for the series celebrating the 40th year since the first issue of Avian Pathology. The aim of the authors was to cover the developments in Newcastle disease (ND) research over the last 40 years that they considered significant. During those 40 years there have been several panzootics of this serious disease in poultry and for the last 30 years there has been a continuing panzootic in domestic pigeons, which has spread to wild birds and poultry. The 40-year period began with worldwide outbreaks of severe ND, which served as an important impetus for ND research work. Although early work was concerned with controlling the disease, specifically by improving and developing new vaccines and vaccine regimens, even prior to the 1970s ND virus was seen as a useful laboratory virus for replication and virulence studies. This review covers the historical developments in the following areas: understanding the molecular basis of virulence; epidemiology and relatedness of different ND strains, both antigenically and genetically; the emergence of virulent strains and their relationship with viruses of low virulence; sequencing and understanding the viral genome and genes; the development of rapid molecular-based diagnostic tests; and the phylogeny and molecular taxonomy of ND virus. The authors suggest areas in which future research could or should be undertaken.
- Subjects :
- medicine.medical_specialty
Newcastle Disease
Newcastle disease virus
Virulence
Genome, Viral
Disease
Biology
Newcastle disease
Poultry
Virus
Molecular taxonomy
Birds
Food Animals
Epidemiology
medicine
Animals
Humans
Pandemics
Phylogeny
Poultry Diseases
Panzootic
General Immunology and Microbiology
Outbreak
biology.organism_classification
Virology
Animal Science and Zoology
Subjects
Details
- ISSN :
- 14653338 and 03079457
- Volume :
- 41
- Database :
- OpenAIRE
- Journal :
- Avian Pathology
- Accession number :
- edsair.doi.dedup.....c4fed86a19274cb224eb995878fb8a2f