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A comparative analysis of longitudinal computed tomography and histopathology for evaluating the potential of mesenchymal stem cells in mitigating radiation-induced pulmonary fibrosis
- Source :
- Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017), Scientific Reports
- Publication Year :
- 2017
- Publisher :
- Springer Science and Business Media LLC, 2017.
-
Abstract
- Radiation-induced pulmonary fibrosis (RIPF) is a debilitating side effect that occurs in up to 30% of thoracic irradiations in breast and lung cancer patients. RIPF remains a major limiting factor to dose escalation and an obstacle to applying more promising new treatments for cancer cure. Limited treatment options are available to mitigate RIPF once it occurs, but recently, mesenchymal stem cells (MSCs) and a drug treatment stimulating endogenous stem cells (GM-CSF) have been investigated for their potential in preventing this disease onset. In a pre-clinical rat model, we contrasted the application of longitudinal computed tomography (CT) imaging and classical histopathology to quantify RIPF and to evaluate the potential of MSCs in mitigating RIPF. Our results on histology demonstrate promises when MSCs are injected endotracheally (but not intravenously). While our CT analysis highlights the potential of GM-CSF treatment. Advantages and limitations of both analytical methods are contrasted in the context of RIPF.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Pathology
Side effect
Biopsy
Pulmonary Fibrosis
Science
Context (language use)
Article
03 medical and health sciences
0302 clinical medicine
Pulmonary fibrosis
medicine
Animals
Radiation Injuries
Lung cancer
Multidisciplinary
Radiotherapy
business.industry
Mesenchymal stem cell
Cancer
Mesenchymal Stem Cells
medicine.disease
Rats
3. Good health
Disease Models, Animal
030104 developmental biology
030220 oncology & carcinogenesis
Medicine
Female
Histopathology
Stem cell
Tomography, X-Ray Computed
business
Subjects
Details
- ISSN :
- 20452322
- Volume :
- 7
- Database :
- OpenAIRE
- Journal :
- Scientific Reports
- Accession number :
- edsair.doi.dedup.....c4f87df1c92470a1d5bf8f7dd335b738