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Prognosis in advanced lung cancer--A prospective study examining key clinicopathological factors
- Source :
- Simmons, C, Koinis, P, Fallon, M, Fearon, K, Bowden, J, Solheim, T, Gronberg, B, McMillan, D, Gioulbasanis, I & Laird, B 2015, ' Prognosis in advanced lung cancer-a prospective study of examining key clinicopathological factors ', Lung Cancer, vol. 88, no. 3, pp. 304-309 . https://doi.org/10.1016/j.lungcan.2015.03.020
- Publication Year :
- 2014
-
Abstract
- ObjectivesIn patients with advanced incurable lung cancer deciding as to the most appropriate treatment (e.g. chemotherapy or supportive care only) is challenging. In such patients the TNM classification system has reached its ceiling therefore other factors are used to assess prognosis and as such guide treatment. Performance status (PS), weight loss and inflammatory biomarkers (Glasgow Prognostic Score (mGPS)) predict survival in advanced lung cancer however these have not been compared. This study compares key prognostic factors in advanced lung cancer.Materials and methodsPatients with newly diagnosed advanced lung cancer were recruited and demographics, weight loss, other prognostic factors (mGPS, PS) were collected. Kaplan-Meier and Cox regression methods were used to compare these prognostic factors.Results390 patients with advanced incurable lung cancer were recruited; 341 were male, median age was 66 years (IQR 59-73) and patients had stage 4 non-small cell (n = 288) (73.8%) or extensive stage small cell lung cancer (n = 102) (26.2%). The median survival was 7.8 months. On multivariate analysis only performance status (HR 1.74 CI 1.50-2.02) and mGPS (HR 1.67, CI 1.40-2.00) predicted survival (p < 0.001). Survival at 3 months ranged from 99% (ECOG 0-1) to 74% (ECOG 2) and using mGPS, from 99% (mGPS0) to 71% (mGPS2). In combination, survival ranged from 99% (mGPS 0, ECOG 0-1) to 33% (mGPS2, ECOG 3).ConclusionPerformance status and the mGPS are superior prognostic factors in advanced lung cancer. In combination, these improved survival prediction compared with either alone.
- Subjects :
- Oncology
Pulmonary and Respiratory Medicine
Male
medicine.medical_specialty
Cancer Research
Multivariate analysis
Cachexia
Lung Neoplasms
medicine.medical_treatment
Weight loss
Internal medicine
Weight Loss
medicine
Humans
Prospective Studies
Lung cancer
Prospective cohort study
Aged
Neoplasm Staging
Inflammation
Chemotherapy
Performance status
Proportional hazards model
business.industry
Middle Aged
medicine.disease
Prognosis
Survival Analysis
Surgery
Female
medicine.symptom
business
CRP
Subjects
Details
- ISSN :
- 18728332 and 01695002
- Volume :
- 88
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Lung cancer (Amsterdam, Netherlands)
- Accession number :
- edsair.doi.dedup.....c4f85f1f058e5dafca17934729edfceb