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CPAG: software for leveraging pleiotropy in GWAS to reveal similarity between human traits links plasma fatty acids and intestinal inflammation
- Source :
- Genome Biology
- Publication Year :
- 2015
-
Abstract
- Meta-analyses of genome-wide association studies (GWAS) have demonstrated that the same genetic variants can be associated with multiple diseases and other complex traits. We present software called CPAG (Cross-Phenotype Analysis of GWAS) to look for similarities between 700 traits, build trees with informative clusters, and highlight underlying pathways. Clusters are consistent with pre-defined groups and literature-based validation but also reveal novel connections. We report similarity between plasma palmitoleic acid and Crohn's disease and find that specific fatty acids exacerbate enterocolitis in zebrafish. CPAG will become increasingly powerful as more genetic variants are uncovered, leading to a deeper understanding of complex traits. CPAG is freely available at www.sourceforge.net/projects/CPAG/. Electronic supplementary material The online version of this article (doi:10.1186/s13059-015-0722-1) contains supplementary material, which is available to authorized users.
- Subjects :
- Genetics
Enterocolitis
Genome-wide association study
Genetic Pleiotropy
Computational biology
Disease
Biology
biology.organism_classification
Phenotype
Polymorphism, Single Nucleotide
Human genetics
3. Good health
Fatty Acids, Monounsaturated
Crohn Disease
Pleiotropy
Animals
Cluster Analysis
Humans
Zebrafish
Software
Genetic association
Genome-Wide Association Study
Subjects
Details
- ISSN :
- 1474760X
- Volume :
- 16
- Database :
- OpenAIRE
- Journal :
- Genome biology
- Accession number :
- edsair.doi.dedup.....c4f1e73b94f360f16fb26057f0a08849