The excretion of activity following the administration of 1,1-di(4-chlorophenyl)-2-chloroethylene-ring-UL-14C(14C-DDMU) to Japanese quail

DDT and to a lesser extent DDD were until recently used extensively in agriculture and horticulture as insecticides. The metabolism of DDT was first investigated in the rabbit (WHITE, 1945) but it was only in 1964 that a complete metabolic pathway was proposed for the conversion of DDT to DDA in the rat (PETERSON and ROBISON 1964). This involved the initial conversion of DDT to DDE or DDD and the subsequent conversion of DDD to DDA by a series of alternate dehydrohalogenation and hydrogenation stages with a final oxidation step to DDA.