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Clinicopathologic profile, immunophenotype, and genotype of CD274 (PD-L1)-positive colorectal carcinomas
- Source :
- Mod Pathol
- Publication Year :
- 2016
-
Abstract
- The CD274 (PD-L1)/PDCD1 (PD-1) pathway is crucial for the modulation of immune responses and self-tolerance. Aberrantly expressed CD274 allows tumor cells to evade host immune system and is considered to be a mechanism of adaptive immune resistance. Inhibition of the CD274/PDCD1 immune checkpoint offers a promising new therapeutic strategy. Although CD274-expressing tumor cells have been identified in different types of tumors including colorectal cancer, clinicopathologic profile of these CD274-positive tumors has not been extensively studied. In this study, 454 primary colorectal carcinomas were analyzed histologically and immunohistochemically for CD274, mismatch repair (MMR) proteins, intestinal differentiation marker (CDX2), and stem cell markers (ALCAM, ALDH1A1, and SALL4). CD274-positive colorectal carcinomas (54/454 (12%)) usually (83%) involved the right or transverse colon with poorly differentiated and solid/medullary histology. On the basis of multivariate logistic regression analysis, CD274 positivity was significantly associated with poorly differentiated histotype (OR: 3.32; 95% CI: 1.46–7.51; P = 0.004), MMR deficiency (OR: 10.0; 95% CI: 4.66–21.5; P
- Subjects :
- 0301 basic medicine
Fetal Proteins
Male
Proto-Oncogene Proteins B-raf
Pathology
medicine.medical_specialty
Genotype
Colorectal cancer
Cell Adhesion Molecules, Neuronal
DNA Mutational Analysis
Biology
Stem cell marker
DNA Mismatch Repair
PD-L1 Positive
Aldehyde Dehydrogenase 1 Family
B7-H1 Antigen
Article
Pathology and Forensic Medicine
Immunophenotyping
03 medical and health sciences
0302 clinical medicine
SALL4
Antigens, CD
Carcinoma
medicine
Humans
CDX2 Transcription Factor
ALCAM
Aged
Aged, 80 and over
Retinal Dehydrogenase
Aldehyde Dehydrogenase
Middle Aged
medicine.disease
Immunohistochemistry
Immune checkpoint
030104 developmental biology
030220 oncology & carcinogenesis
Carcinoma, Medullary
Mutation
Female
Colorectal Neoplasms
Transcription Factors
Subjects
Details
- ISSN :
- 15300285
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc
- Accession number :
- edsair.doi.dedup.....c4e614f7e3a1488d9c826d6558fe3345