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Glucose Levels During Gestational Diabetes Pregnancy and the Risk of Developing Postpartum Diabetes or Prediabetes
- Source :
- BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-8 (2022), BMC Pregnancy and Childbirth
- Publication Year :
- 2020
- Publisher :
- Research Square Platform LLC, 2020.
-
Abstract
- Background Blood glucose levels during pregnancy may reflect the severity of insulin secretory defects and/or insulin resistance during gestational diabetes mellitus (GDM) pregnancy. We hypothesized that suboptimal glycemic control in women with GDM could increase the risk of postpartum type 2 diabetes mellitus (T2DM) or prediabetes. Our objective was to evaluate the impact of plasma glucose levels throughout GDM pregnancy on the risk of postpartum T2DM or prediabetes. Methods The medical records of 706 women with GDM who underwent a postpartum 75-g, 2-hour oral glucose tolerance test at our institution between January 2011 and December 2018 were reviewed. These women were classified into 2 groups according to glycemic control during pregnancy: ≤ 1 occasion of either fasting glucose ≥ 95 mg/dL or 2-hour postprandial glucose ≥ 120 mg/dL was defined as optimal glycemic control or else was classified as suboptimal glycemic control. Rates of postpartum T2DM and prediabetes were compared between women with optimal (n = 505) and suboptimal (n = 201) glycemic control. Results The rates of postpartum T2DM and prediabetes were significantly higher in the suboptimal glycemic control group than in the optimal glycemic control group: 22.4% vs. 3.0%, P < 0.001 for T2DM and 45.3% vs. 23.5%, P < 0.001 for prediabetes. In a multivariate analysis, suboptimal glucose control during pregnancy was an independent risk factor for developing either postpartum T2DM or prediabetes. The adjusted odds ratios were 8.4 (95% confidence interval, 3.5–20.3) for T2DM and 3.9 (95% confidence interval, 2.5–6.1) for prediabetes. Conclusion Our findings suggest that blood glucose levels during GDM pregnancy have an impact on the risk of postpartum T2DM and prediabetes.
- Subjects :
- Adult
Blood Glucose
medicine.medical_specialty
endocrine system diseases
Gestational diabetes mellitus
Prediabetic State
Glucose level
Glycemic control
Pregnancy
Risk Factors
Postpartum type 2 diabetes mellitus
medicine
Humans
Prediabetes
Postpartum prediabetes
Retrospective Studies
business.industry
Obstetrics
Postpartum Period
Obstetrics and Gynecology
nutritional and metabolic diseases
Gynecology and obstetrics
Postpartum diabetes
Glucose Tolerance Test
Thailand
medicine.disease
Gestational diabetes
Diabetes, Gestational
Diabetes Mellitus, Type 2
RG1-991
Female
business
Research Article
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- BMC Pregnancy and Childbirth, Vol 22, Iss 1, Pp 1-8 (2022), BMC Pregnancy and Childbirth
- Accession number :
- edsair.doi.dedup.....c4d626ad08bc7f5c2580abddafbfce79