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A Preliminary Study of the Association between Apolipoprotein E Promoter Methylation and Atherosclerotic Cerebral Infarction
- Source :
- Journal of Stroke and Cerebrovascular Diseases. 28:1056-1061
- Publication Year :
- 2019
- Publisher :
- Elsevier BV, 2019.
-
Abstract
- To investigate association of Apolipoprotein E (ApoE) gene promoter methylation with atherosclerotic cerebral infarction (ACI) in the Han Chinese population.Twenty-six ACI patients (the case group) and 26 healthy (the control group) were recruited randomly from Henan Han nationality population, from April 2016 to August 2016. Bisulfite pyrosequencing technology was used to examine the role of the aberrant gene promoter methylation in ACI in Han Chinese population. Especially, we used the odds ratio and 95% confidence interval (95% CI) method to elevate the correlation between ApoE Promoter Methylation and ACI.The case group was significantly more likely to have hypertension and carotid atherosclerotic plaques (Table 1). The case group had significantly lower levels of high-density lipoprotein cholesterol (HDL-C), folate, and higher levels of homocysteine (Table 2). We observed that ACI patients (n = 26) had significantly higher methylation levels at cytosine-phosphate-guanine (CpG) 14 and CpG16 compared with controls (n = 26) (Table 3). Importantly, our results indicated a significant association between ApoE promoter methylation and ACI (OR = 16.146; 95% CI, 1.154-225.832; P*.05; P*: adjusted for age, gender, carotid atherosclerotic plaque, hypertension, HDL-C, homocysteine, and folate) (Table 4).Our study indicates that ApoE promoter methylation may be associated with ACI in Han Chinese people.
- Subjects :
- Adult
Male
Apolipoprotein E
China
medicine.medical_specialty
Homocysteine
education
Population
Risk Assessment
03 medical and health sciences
chemistry.chemical_compound
Apolipoproteins E
0302 clinical medicine
Asian People
Risk Factors
Internal medicine
Humans
Medicine
Genetic Predisposition to Disease
Epigenetics
Promoter Regions, Genetic
Genetic Association Studies
Aged
education.field_of_study
business.industry
Cerebral infarction
Rehabilitation
Promoter
Cerebral Infarction
Methylation
Odds ratio
DNA Methylation
Middle Aged
Intracranial Arteriosclerosis
medicine.disease
Phenotype
Endocrinology
chemistry
Case-Control Studies
CpG Islands
Female
Surgery
Neurology (clinical)
Cardiology and Cardiovascular Medicine
business
030217 neurology & neurosurgery
Preliminary Data
Subjects
Details
- ISSN :
- 10523057
- Volume :
- 28
- Database :
- OpenAIRE
- Journal :
- Journal of Stroke and Cerebrovascular Diseases
- Accession number :
- edsair.doi.dedup.....c4bfa8f8b4f5edb89a60a95192820788