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Cardiotoxicity due to targeted anticancer agents: a growing challenge
- Source :
- Therapeutic Advances in Cardiovascular Disease, Therapeutic Advances in Cardiovascular Disease, Vol 13 (2019)
- Publication Year :
- 2019
- Publisher :
- SAGE Publications, 2019.
-
Abstract
- The emergence of various targeted anticancer agents has led us to uncharted territory secondary to their cardiotoxic potential with many burning questions, which in turn has led to the evolution of the cardio-oncology field. These targeted agents differ in their cardiovascular complication (CVC) potential even within the same class and it is very difficult to design screening tests that can predict CVCs. Moreover, there is a need for more research to answer many crucial questions, since these toxicities are unanticipated and can lead to poor overall survival of cancer patients. We still do not clearly understand the mechanism for such toxicity, risk factors, and natural history. A better understanding of the underlying risk factors and identification of biomarkers would help us develop protocols for appropriate monitoring strategies which in turn would help capture these toxicities at early stages. In this succinct review, we try to focus on CVC definition, summarize some published research, and point to areas of unmet need in this new field.
- Subjects :
- Cardiovascular toxicity
lcsh:Diseases of the circulatory (Cardiovascular) system
cardiovascular toxicity
targeted agents
Heart Diseases
cardiotoxicity
Antineoplastic Agents
030204 cardiovascular system & hematology
Bioinformatics
Risk Assessment
03 medical and health sciences
0302 clinical medicine
Risk Factors
Medicine
cancer
Animals
Humans
Pharmacology (medical)
Molecular Targeted Therapy
Cardiotoxicity
therapy
business.industry
Cancer
medicine.disease
Prognosis
Editorial
lcsh:RC666-701
030220 oncology & carcinogenesis
Cardiology and Cardiovascular Medicine
business
Subjects
Details
- Language :
- English
- ISSN :
- 17539455 and 17539447
- Volume :
- 13
- Database :
- OpenAIRE
- Journal :
- Therapeutic Advances in Cardiovascular Disease
- Accession number :
- edsair.doi.dedup.....c4b73fa3b02ec778912065db630aca3c