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Protein phase separation and its role in tumorigenesis
- Source :
- eLife, Vol 9 (2020), eLife
- Publication Year :
- 2020
- Publisher :
- eLife Sciences Publications Ltd, 2020.
-
Abstract
- Cancer is a disease characterized by uncontrolled cell proliferation, but the precise pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent years, condensates formed by phase separation have emerged as a new principle governing the organization and functional regulation of cells. Increasing evidence links cancer-related mutations to aberrantly altered condensate assembly, suggesting that condensates play a key role in tumorigenesis. In this review, we summarize and discuss the latest progress on the formation, regulation, and function of condensates. Special emphasis is given to emerging evidence regarding the link between condensates and the initiation and progression of cancers.
- Subjects :
- 0301 basic medicine
Mouse
Carcinogenesis
S. cerevisiae
Review Article
Promyelocytic Leukemia Protein
medicine.disease_cause
Mice
0302 clinical medicine
Neoplasms
Cancer biology
Neoplasm Metastasis
Biology (General)
Cancer Biology
Neovascularization, Pathologic
General Neuroscience
General Medicine
Cell biology
Cell Transformation, Neoplastic
030220 oncology & carcinogenesis
C. elegans
Disease Progression
Medicine
Human
Signal Transduction
Amyloid
QH301-705.5
Science
Saccharomyces cerevisiae
Biology
General Biochemistry, Genetics and Molecular Biology
03 medical and health sciences
Escherichia coli
medicine
Animals
Humans
cancer
Neoplasm Invasiveness
Caenorhabditis elegans
Organelles
membraneless organelle
General Immunology and Microbiology
Cell growth
E. coli
Proteins
Wnt Proteins
030104 developmental biology
Mutation
biomolecular condensate
phase separation
Function (biology)
DNA Damage
Subjects
Details
- Language :
- English
- Volume :
- 9
- Database :
- OpenAIRE
- Journal :
- eLife
- Accession number :
- edsair.doi.dedup.....c4b1ae7ff0779a88e01c7bd275477be8