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Age, sex, and the vascular contributors to cerebral pulsatility and pulsatile damping
- Source :
- Journal of Applied Physiology
- Publication Year :
- 2020
- Publisher :
- American Physiological Society, 2020.
-
Abstract
- Cerebral pulsatility reflects a balance between the transmission and damping of pulsatility in the cerebrovasculature. Females experience greater cerebral pulsatility with aging, which may have implications for sex differences in stroke risk and cognitive decline. This study sought to explore vascular contributors to cerebral pulsatility and pulsatile damping in men and women. Adults (n = 282, 53% female) underwent measurements of cerebral (middle cerebral artery) pulsatility, pulsatile damping (ratio of cerebral to carotid pulsatility), large artery stiffening (ratio of aortic to carotid pulse wave velocity), and carotid wave transmission/reflection dynamics using wave intensity analysis. Multiple regression revealed that older age, female sex, greater large artery stiffening, higher carotid pulse pressure, and greater forward wave energy was associated with increased cerebral pulsatility (adjusted R2 = 0.44, P < 0.05). Contributors to decreased cerebral pulsatile damping included older age, female sex, and lower wave reflection index (adjusted R2 = 0.51, P < 0.05). Our data link greater large artery stiffening, carotid pulse pressure, and forward wave energy to greater cerebral pulsatility, while greater carotid wave reflection may enhance cerebral pulsatile damping. Lower cerebral pulsatile damping among females may contribute to greater age-associated cerebral pulsatile burden compared with males. NEW & NOTEWORTHY Cerebral pulsatility contributes to brain health and depends on a balance between transmission and damping of pulsatile hemodynamics into the cerebrovasculature. Our data indicate that cerebral pulsatility increases with age, female sex, extracranial artery stiffening, forward wave energy, and pulse pressure, whereas pulsatile damping decreases with age and female sex and increases with greater carotid wave reflections. These novel data identify pulsatile damping as a potential contributor to sex differences in cerebral pulsatile burden.
- Subjects :
- sex differences
Adult
Male
medicine.medical_specialty
Physiology
Pulsatile flow
Hemodynamics
Blood Pressure
Pulse Wave Analysis
030204 cardiovascular system & hematology
Carotid Intima-Media Thickness
03 medical and health sciences
Vascular Stiffness
0302 clinical medicine
Physiology (medical)
Internal medicine
Humans
Medicine
wave reflections
Aged
Balance (ability)
business.industry
pulsatile damping
aging
artery stiffness
pulsatility
medicine.disease
Carotid Arteries
Pulsatile Flow
Cardiology
Arterial stiffness
Female
business
Blood Flow Velocity
030217 neurology & neurosurgery
Research Article
Subjects
Details
- ISSN :
- 15221601 and 87507587
- Volume :
- 129
- Database :
- OpenAIRE
- Journal :
- Journal of Applied Physiology
- Accession number :
- edsair.doi.dedup.....c4b1300c2e26e0c789c2f69d62cb4d89