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Overall and cancer-specific survival in patients with breast Paget disease: A population-based study
Overall and cancer-specific survival in patients with breast Paget disease: A population-based study
- Source :
- Exp Biol Med (Maywood)
- Publication Year :
- 2021
-
Abstract
- Paget disease of the breast is an uncommon malignant tumor with an inferior outcome. Therefore, establishing nomograms to predict the survival outcomes of breast Paget disease patients is urgent. Clinicopathological and follow-up data of breast Paget disease patients diagnosed between 2010 and 2016 were retrieved through the Surveillance, Epidemiology, and End Result (SEER) database. The significant factors were screened out, and then those factors were utilized to build two valuable nomograms. The discriminative ability of nomograms was investigated using concordance-index (C-index), while the predictive accuracy and benefits were evaluated using calibration curves and decision curve analysis. Finally, a total of 417 breast Paget disease patients were enrolled. Tumor grade, histological type, American Joint Committee on Cancer (AJCC) stage, surgery, chemotherapy, and marital status were confirmed as independent overall survival (OS)-related factors; tumor grade, histological type, AJCC stage, and age were associated with independent cancer-specific survival (CSS)-related factors. The values of the C-index for OS nomogram acquired were 0.827 and 0.745 for training and validation cohorts, respectively. Meanwhile, the corresponding values of the C-index to CSS nomogram were 0.890 and 0.655, respectively. The calibration curves and decision curve analysis indicated that both nomograms had an excellent performance. Finally, the nomogram-based risk stratification system indicated that all breast Paget disease patients could be classified into low- and high-risk groups and showed distinct outcomes. In conclusion, two valuable nomograms incorporating various clinicopathological indicators were established for breast Paget disease patients. These prognostic nomograms provide accurate prognostic assessment for breast Paget disease patients and help clinicians select appropriate treatment strategies.
- Subjects :
- Oncology
Adult
medicine.medical_specialty
genetic structures
medicine.medical_treatment
Paget's Disease, Mammary
Breast Neoplasms
urologic and male genital diseases
General Biochemistry, Genetics and Molecular Biology
Cancer specific survival
Breast cancer
Internal medicine
Epidemiology
Paget Disease
Medicine
Humans
Stage (cooking)
Aged
Original Research
Chemotherapy
business.industry
Cancer
Nomogram
Middle Aged
medicine.disease
Prognosis
Nomograms
Female
business
SEER Program
Subjects
Details
- ISSN :
- 15353699
- Volume :
- 247
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- Experimental biology and medicine (Maywood, N.J.)
- Accession number :
- edsair.doi.dedup.....c4af9542e43b48c5778985ab2bd10edd