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Association between heavy metal levels and acute ischemic stroke
- Source :
- Journal of Biomedical Science, Vol 25, Iss 1, Pp 1-8 (2018), Journal of Biomedical Science
- Publication Year :
- 2018
- Publisher :
- BMC, 2018.
-
Abstract
- Background Few studies have examined the relationship between the amounts of heavy metal and stroke incidence. The aim of this study was to explore the relationship between levels of heavy metals, including Pb, Hg, As, and Cd, in patients with acute ischemic stroke (AIS). Methods We selected patients with first-ever AIS onset within 1 week as our study group. Healthy controls were participants without a history of stroke or chronic disease, except hypertension. The serum levels of Pb, Hg, As, and Cd in participants in the experimental and control groups were determined. All participants received a 1-g infusion of edetate calcium disodium (EDTA). Urine specimens were collected for 24 h after EDTA infusion and measured for heavy metal levels. Results In total, 33 patients with AIS and 39 healthy controls were enrolled in this study. The major findings were as follows: (1) The stroke group had a significantly lower level of serum Hg (6.4 ± 4.3 μg/L vs. 9.8 ± 7.0 μg/L, P = 0.032, OR = 0.90, 95% CI = 0.81–0.99) and a lower level of urine Hg (0.7 ± 0.7 μg/L vs. 1.2 ± 0.6 μg/L, P = 0.006, OR = 0.27, 95% CI = 0.11–0.68) than the control group. (2) No significant difference in serum Pb (S-Pb), As (S-As), and Cd (S-Cd) levels and urine Pb (U-Pb), As (U-As) and Cd (U-Cd) levels was observed in either group. Conclusions Our study found low levels of serum and urine Hg in first-ever patients with AIS, providing new evidence of dysregulated heavy metals in patients with AIS. Electronic supplementary material The online version of this article (10.1186/s12929-018-0446-0) contains supplementary material, which is available to authorized users.
- Subjects :
- Male
medicine.medical_specialty
Endocrinology, Diabetes and Metabolism
Clinical Biochemistry
Acute ischemic stroke
Taiwan
lcsh:Medicine
Urine
EDETATE CALCIUM DISODIUM
030204 cardiovascular system & hematology
010501 environmental sciences
01 natural sciences
Gastroenterology
Brain Ischemia
Arsenic
03 medical and health sciences
0302 clinical medicine
Internal medicine
Metals, Heavy
Medicine
Humans
Pharmacology (medical)
In patient
Molecular Biology
0105 earth and related environmental sciences
Aged
business.industry
Incidence
Research
Biochemistry (medical)
Significant difference
lcsh:R
Heavy metals
Cell Biology
General Medicine
Mercury
Middle Aged
Stroke
Chronic disease
Heavy metal
Lead
Environmental Pollutants
Female
business
Stroke incidence
Cadmium
Subjects
Details
- Language :
- English
- ISSN :
- 14230127
- Volume :
- 25
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- Journal of Biomedical Science
- Accession number :
- edsair.doi.dedup.....c491026f5dfad3cf6596b84e25caecc8