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Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant

Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant

Authors :
Teresa Caballero Velázquez
D Caballero
María Díez-Campelo
Lourdes Vázquez
Fermín Sánchez-Guijo
Fernando Capela e Silva
Jesús F. San Miguel
Jesús Martín
José A. Pérez-Simón
Cristina Encinas
Fernanda Villanueva-Gomez
Enrique Colado
Consuelo del Cañizo
Source :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Publication Year :
2010
Publisher :
Wiley-Blackwell, 2010.

Abstract

Chronic graft-versus-host disease (cGVHD) is the major late complication after allogeneic hematopoietic stem cell transplant [1,2]. In this article, we have analyzed the value of noninvasive day 1100 tests as predictors of severe cGVHD development in 165 patients undergoing allogeneic peripheral blood stem cell transplant (allo-PBSCT) from a matched related donor. The cumulative incidence of overall, extensive, and severe cGVHD was 67, 56, and 23%, respectively, among patients surviving >100 days after transplant. In univariate analysis, patients displaying an abnormal liver function tests (LFTs) (total bilirubin, alkaline phosphatase, and GGT > 2 times above the upper normal limit) and a low absolute lymphocyte count (ALC) (

Details

Database :
OpenAIRE
Journal :
Digital.CSIC. Repositorio Institucional del CSIC, instname
Accession number :
edsair.doi.dedup.....c48e0f075de9f197f6556902286e3d43