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Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant
Liver function tests and absolute lymphocyte count at day +100 are predictive factors for extensive and severe chronic graft-versus-host disease after allogeneic peripheral blood stem cell transplant
- Source :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Publication Year :
- 2010
- Publisher :
- Wiley-Blackwell, 2010.
-
Abstract
- Chronic graft-versus-host disease (cGVHD) is the major late complication after allogeneic hematopoietic stem cell transplant [1,2]. In this article, we have analyzed the value of noninvasive day 1100 tests as predictors of severe cGVHD development in 165 patients undergoing allogeneic peripheral blood stem cell transplant (allo-PBSCT) from a matched related donor. The cumulative incidence of overall, extensive, and severe cGVHD was 67, 56, and 23%, respectively, among patients surviving >100 days after transplant. In univariate analysis, patients displaying an abnormal liver function tests (LFTs) (total bilirubin, alkaline phosphatase, and GGT > 2 times above the upper normal limit) and a low absolute lymphocyte count (ALC) (
- Subjects :
- Adult
Male
medicine.medical_specialty
Adolescent
Graft vs Host Disease
Gastroenterology
Severity of Illness Index
Young Adult
Liver Function Tests
Predictive Value of Tests
Risk Factors
Internal medicine
Medicine
Humans
Cumulative incidence
Lymphocyte Count
Increased total bilirubin
Aged
Univariate analysis
Peripheral Blood Stem Cell Transplantation
medicine.diagnostic_test
business.industry
Bilirubin
Hematology
gamma-Glutamyltransferase
Middle Aged
medicine.disease
Alkaline Phosphatase
Graft-versus-host disease
Predictive value of tests
Immunology
Chronic Disease
Abnormal Liver Function Test
Female
Liver function
business
Liver function tests
Subjects
Details
- Database :
- OpenAIRE
- Journal :
- Digital.CSIC. Repositorio Institucional del CSIC, instname
- Accession number :
- edsair.doi.dedup.....c48e0f075de9f197f6556902286e3d43