Back to Search
Start Over
Evaluation of P16 expression in canine appendicular osteosarcoma
- Source :
- BMC Veterinary Research, BMC Veterinary Research, Vol 13, Iss 1, Pp 1-9 (2017), BMC veterinary research, vol 13, iss 1
- Publication Year :
- 2017
-
Abstract
- Background Osteosarcoma (OSA) is a common malignant bone tumor of large breed dogs that occurs at predictable anatomic sites. At the time of initial diagnosis, most affected dogs have occult pulmonary metastases. Even with aggressive surgical treatment combined with chemotherapy, the majority of dogs diagnosed with OSA live less than 1 year from the time of diagnosis. The ability to identify canine OSA cases most responsive to treatment is needed. In humans, OSA is also an aggressive tumor that is histologically and molecularly similar to canine OSA. The expression of the tumor suppressor gene product P16 by human OSA tissue has been linked to a favorable response to chemotherapy. Results We identified an antibody that binds canine P16 and developed a canine OSA tissue microarray in order to test the hypothesis that P16 expression by canine OSA tissue is predictive of clinical outcome following amputation and chemotherapy. Although statistical significance was not reached, a trend was identified between the lack of canine OSA P16 expression and a shorter disease free interval. Conclusions The identification of a molecular marker for canine OSA is an important goal and the results reported here justify a larger study.
- Subjects :
- Pathology
medicine.medical_treatment
p16
Carboplatin
Canine
Tissue microarray
0403 veterinary science
0302 clinical medicine
Surgical
Dog Diseases
Amputation
Lung
Cancer
Osteosarcoma
lcsh:Veterinary medicine
biology
04 agricultural and veterinary sciences
General Medicine
Immunohistochemistry
Gene Expression Regulation, Neoplastic
Treatment Outcome
030220 oncology & carcinogenesis
Antibody
Sleep Research
Research Article
medicine.medical_specialty
Tumor suppressor gene
040301 veterinary sciences
Antineoplastic Agents
Bone Neoplasms
Microbiology
Amputation, Surgical
03 medical and health sciences
Rare Diseases
Dogs
stomatognathic system
medicine
Animals
Veterinary Sciences
Retrospective Studies
Neoplastic
Chemotherapy
General Veterinary
business.industry
Prevention
Genes, p16
P16
medicine.disease
Occult
nervous system diseases
respiratory tract diseases
Orphan Drug
Gene Expression Regulation
Genes
Doxorubicin
biology.protein
lcsh:SF600-1100
Biochemistry and Cell Biology
business
Subjects
Details
- ISSN :
- 17466148
- Volume :
- 13
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- BMC veterinary research
- Accession number :
- edsair.doi.dedup.....c48a52434b4ebe73f3021d6eb4e34d9f