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Natural Products as a Source for Antileishmanial and Antitrypanosomal Agents
- Source :
- Combinatorial Chemistry & High Throughput Screening. 19:537-553
- Publication Year :
- 2016
- Publisher :
- Bentham Science Publishers Ltd., 2016.
-
Abstract
- Natural products are compounds extracted from plants, marine organisms, fungi or bacteria. Many researches for new drugs are based on these natural molecules, mainly by beneficial effects on health, health, efficacy, and therapeutic safety. Leishmaniosis, Chagas disease and African sleeping sickness are neglected diseases caused by the Leishmania and Trypanosoma ssp. parasites. These infections mainly affect population of developing countries; they have different symptoms, and may often lead to death. The therapeutic drugs available to treat these diseases are either obsolete, toxic, or have questionable efficacy, possibly through encountering resistance. Discovery of new, safe, effective, and affordable molecules is urgently needed. Natural organisms, as marine metabolites, alkaloids, flavonoids, steroids, terpene and coumarins provide innumerable molecules with the potential to treat these diseases. This study examines studies of natural bioactive compounds as antileishmanial and antitrypanosomal agents.
- Subjects :
- Chagas disease
Population
Antiprotozoal Agents
Biology
Pharmacology
01 natural sciences
Terpene
Alkaloids
Coumarins
Drug Discovery
medicine
Humans
education
Leishmaniasis
Beneficial effects
Flavonoids
Biological Products
education.field_of_study
010405 organic chemistry
Organic Chemistry
Neglected Diseases
General Medicine
medicine.disease
biology.organism_classification
Leishmania
0104 chemical sciences
Computer Science Applications
010404 medicinal & biomolecular chemistry
Trypanosoma
Steroids
Subjects
Details
- ISSN :
- 13862073
- Volume :
- 19
- Database :
- OpenAIRE
- Journal :
- Combinatorial Chemistry & High Throughput Screening
- Accession number :
- edsair.doi.dedup.....c47274ea2262d736c72667d4468a4756