Back to Search
Start Over
Polygenic risk scores for late smoking initiation associated with the risk of schizophrenia
- Source :
- npj Schizophrenia, Vol 6, Iss 1, Pp 1-7 (2020), NPJ Schizophrenia
- Publication Year :
- 2020
- Publisher :
- Nature Portfolio, 2020.
-
Abstract
- Patients with schizophrenia display characteristic smoking-related behaviors and genetic correlations between smoking behaviors and schizophrenia have been identified in European individuals. However, the genetic etiology of the association remains to be clarified. The present study investigated transethnic genetic overlaps between European-based smoking behaviors and the risk of Japanese schizophrenia by conducting polygenic risk score (PRS) analyses. Large-scale European genome-wide association study (GWAS) datasets (n = 24,114–74,035) related to four smoking-related intermediate phenotypes [(i) smoking initiation, (ii) age at smoking initiation, (iii) smoking quantity, and (iv) smoking cessation] were utilized as discovery samples. PRSs derived from these discovery GWASs were calculated for 332 Japanese subjects [schizophrenia patients, their unaffected first-degree relatives (FRs), and healthy controls (HCs)] as a target sample. Based on GWASs of European smoking phenotypes, we investigated the effects of PRSs on smoking phenotypes and the risk of schizophrenia in the Japanese population. Of the four smoking-related behaviors, the PRSs for age at smoking initiation in Europeans significantly predicted the age at smoking initiation (R2 = 0.049, p = 0.026) and the PRSs for smoking cessation significantly predicted the smoking cessation (R2 = 0.092, p = 0.027) in Japanese ever-smokers. Furthermore, the PRSs related to age at smoking initiation in Europeans were higher in Japanese schizophrenia patients than in the HCs and those of the FRs were intermediate between those of patients with schizophrenia and those of the HCs (R2 = 0.015, p = 0.015). In our target subjects, patients with schizophrenia had a higher mean age at smoking initiation (p = 0.018) and rate of daily smoking initiation after age 20 years (p = 0.023) compared with the HCs. A total of 60.6% of the patients started to smoke before the onset of schizophrenia. These findings suggest that genetic factors affecting late smoking initiation are associated with the risk of schizophrenia.
- Subjects :
- 0301 basic medicine
medicine.medical_specialty
Genetics of the nervous system
medicine.medical_treatment
RC435-571
Genome-wide association study
Daily smoking
behavioral disciplines and activities
Article
03 medical and health sciences
0302 clinical medicine
Genetic etiology
Internal medicine
mental disorders
Medicine
Psychiatry
business.industry
Japanese population
medicine.disease
Psychiatry and Mental health
Smoking initiation
030104 developmental biology
Schizophrenia
Smoking cessation
Polygenic risk score
business
030217 neurology & neurosurgery
Biomarkers
Subjects
Details
- Language :
- English
- Volume :
- 6
- Issue :
- 1
- Database :
- OpenAIRE
- Journal :
- npj Schizophrenia
- Accession number :
- edsair.doi.dedup.....c45d1d71662cbc64d3a03f56efba0884