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Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism
- Source :
- Obesity (Silver Spring, Md.), 17(9), 1671-1677. North American Association for the Study of Obesity, Obesity (Silver Spring, Md.), Obesity (Silver Spring, Md.), 2009, 17 (9), pp.1671-7. ⟨10.1038/oby.2009.102⟩
- Publication Year :
- 2009
-
Abstract
- International audience; The multifactorial mechanisms promoting weight loss and improved metabolism following Roux-en-Y gastric bypass (GB) surgery remain incompletely understood. Recent rodent studies suggest that bile acids can mediate energy homeostasis by activating the G-protein coupled receptor TGR5 and the type 2 thyroid hormone deiodinase. Altered gastrointestinal anatomy following GB could affect enterohepatic recirculation of bile acids. We assessed whether circulating bile acid concentrations differ in patients who previously underwent GB, which might then contribute to improved metabolic homeostasis. We performed cross-sectional analysis of fasting serum bile acid composition and both fasting and post-meal metabolic variables, in three subject groups: (i) post-GB surgery (n = 9), (ii) without GB matched to preoperative BMI of the index cohort (n = 5), and (iii) without GB matched to current BMI of the index cohort (n = 10). Total serum bile acid concentrations were higher in GB (8.90 +/- 4.84 micromol/l) than in both overweight (3.59 +/- 1.95, P = 0.005, Ov) and severely obese (3.86 +/- 1.51, P = 0.045, MOb). Bile acid subfractions taurochenodeoxycholic, taurodeoxycholic, glycocholic, glycochenodeoxycholic, and glycodeoxycholic acids were all significantly higher in GB compared to Ov (P < 0.05). Total bile acids were inversely correlated with 2-h post-meal glucose (r = -0.59, P < 0.003) and fasting triglycerides (r = -0.40, P = 0.05), and positively correlated with adiponectin (r = -0.48, P < 0.02) and peak glucagon-like peptide-1 (GLP-1) (r = 0.58, P < 0.003). Total bile acids strongly correlated inversely with thyrotropic hormone (TSH) (r = -0.57, P = 0.004). Together, our data suggest that altered bile acid levels and composition may contribute to improved glucose and lipid metabolism in patients who have had GB.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
medicine.drug_class
Endocrinology, Diabetes and Metabolism
Glycocholic acid
Gastric Bypass
Medicine (miscellaneous)
Thyrotropin
Severity of Illness Index
Article
Body Mass Index
Bile Acids and Salts
chemistry.chemical_compound
Endocrinology
Blood serum
Glucagon-Like Peptide 1
Internal medicine
medicine
Humans
Obesity
Triglycerides
Nutrition and Dietetics
Adiponectin
Bile acid
Chemistry
Lipid metabolism
Metabolism
Fasting
Middle Aged
Postprandial Period
G protein-coupled bile acid receptor
Up-Regulation
Cross-Sectional Studies
Treatment Outcome
Case-Control Studies
Female
Taurodeoxycholic acid
Biomarkers
Subjects
Details
- Language :
- English
- ISSN :
- 19307381
- Database :
- OpenAIRE
- Journal :
- Obesity (Silver Spring, Md.), 17(9), 1671-1677. North American Association for the Study of Obesity, Obesity (Silver Spring, Md.), Obesity (Silver Spring, Md.), 2009, 17 (9), pp.1671-7. ⟨10.1038/oby.2009.102⟩
- Accession number :
- edsair.doi.dedup.....c44fc9344bccc6fe947305015fb1406a