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Hierarchical Micro-/Nanostructures from Human Hair for Biomedical Applications
- Source :
- Advanced Materials. 30:1800836
- Publication Year :
- 2018
- Publisher :
- Wiley, 2018.
-
Abstract
- With the prominent progress of biomedical engineering, materials with high biocompatibility and versatile functions are urgently needed. So far, hierarchical structures in nature have shed some light on the design of high performance materials both in concept and implementation. Inspired by these, the hierarchical micro-/nanostructures of human hair are explored and human hair is further broken into hierarchical microparticles (HMP) and hierarchical nanoparticles (HNP) with top-down procedures. Compared with commercialized carriers, such as liposomes or albumin nanoparticles, the obtained particles exhibit high hemocompatibility and negligible immunogenicity. Furthermore, these materials also display attentional abilities in the aspects of light absorption and free radical scavenging. It is found that HMP and HNP can prevent skin from UV-induced damage and relieve symptoms of cataract in vitro. Besides, both HMP and HNP show satisfactory photothermal conversion ability. By using microcomputed tomography and intravital fluorescence microscopy, it is found that warfarin-loaded HMP can rescue mice from vein thrombosis. In another aspect, HNP modified with tumor targeted aptamers exhibit dramatic antineoplastic effect, and suppress 96.8% of tumor growth in vivo. Thus, the multifaceted materials described here might provide a new tool for addressing biomedical challenges.
- Subjects :
- Materials science
Nanostructure
Biocompatibility
Aptamer
Nanoparticle
Antineoplastic Agents
Nanotechnology
02 engineering and technology
010402 general chemistry
01 natural sciences
Mice
In vivo
Fluorescence microscope
Animals
Humans
General Materials Science
Tumor growth
Liposome
Mechanical Engineering
X-Ray Microtomography
021001 nanoscience & nanotechnology
Nanostructures
0104 chemical sciences
Mechanics of Materials
Nanoparticles
0210 nano-technology
Hair
Subjects
Details
- ISSN :
- 09359648
- Volume :
- 30
- Database :
- OpenAIRE
- Journal :
- Advanced Materials
- Accession number :
- edsair.doi.dedup.....c4418242b0b729c9a808ab0d171d52e5