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Persistently Elevated C-Reactive Protein Level in the First Year of Antiretroviral Therapy, Despite Virologic Suppression, Is Associated With HIV Disease Progression in Resource-Constrained Settings
- Source :
- Journal of Infectious Diseases. 213:1074-1078
- Publication Year :
- 2015
- Publisher :
- Oxford University Press (OUP), 2015.
-
Abstract
- A case-cohort analysis of human immunodeficiency virus (HIV)–infected individuals receiving antiretroviral therapy (ART) was performed within a multicountry randomized trial (PEARLS) to assess the prevalence of persistently elevated C-reactive protein (CRP) levels, based on serial measurements of CRP levels, and their association with HIV clinical failure. A persistently elevated CRP level in plasma (defined as ≥ 5 mg/L at both baseline and 24 weeks after ART initiation) was observed in 50 of 205 individuals (24%). A persistently elevated CRP level but not an elevated CRP level only at a single time point was independently associated with increased clinical failure, compared with a persistently low CRP level, despite achievement of virologic suppression. Serial monitoring of CRP levels could identify individuals who are at highest risk of HIV progression and may benefit from future adjunct antiinflammatory therapies.
- Subjects :
- Adult
Male
0301 basic medicine
medicine.medical_specialty
Anti-HIV Agents
Resource constrained
Human immunodeficiency virus (HIV)
HIV Infections
Global Health
medicine.disease_cause
law.invention
Major Articles and Brief Reports
03 medical and health sciences
0302 clinical medicine
Elevated C-reactive protein level
Randomized controlled trial
law
Internal medicine
medicine
Humans
Immunology and Allergy
Treatment Failure
030212 general & internal medicine
Inflammation
biology
business.industry
C-reactive protein
Case-control study
Antiretroviral therapy
C-Reactive Protein
030104 developmental biology
Infectious Diseases
Case-Control Studies
Immunology
biology.protein
Female
business
Hiv disease
Subjects
Details
- ISSN :
- 15376613 and 00221899
- Volume :
- 213
- Database :
- OpenAIRE
- Journal :
- Journal of Infectious Diseases
- Accession number :
- edsair.doi.dedup.....c43ecb177b78c7481772131fcdf53549