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Determinants of the transition from a cardiometabolic normal to abnormal overweight/obese phenotype in a Spanish population
- Source :
- European Journal of Nutrition. 53:1345-1353
- Publication Year :
- 2013
- Publisher :
- Springer Science and Business Media LLC, 2013.
-
Abstract
- There is limited prospective evidence at population scale of the impacts of lifestyle and surrogate measures of general and abdominal adiposity on the transition of a metabolically healthy (absence of a metabolic disorder) overweight/obese (MHOO) phenotype to a metabolically abnormal overweight/obese (MAOO) phenotype. Therefore, we determined the relationship between 10-year body mass index (BMI), waist circumferences (WC), waist to height ratio (WHtR), and lifestyle changes and the transition of the MHOO phenotype.We conducted a prospective population-based study of 3,052 male and female Spaniards aged 25-74 years who were followed from 2000 through 2009. Diet and leisure-time physical activity were recorded on validated questionnaires. Weight, height, WC, blood lipids, glycemia, and blood pressure were measured. All variables were obtained at baseline (BL) and follow-up (FL). Participants with a BMI ≥ 25 kg/m(2) and free from hypercholesterolemia, hypertriglyceridemia, diabetes, hypertension, and low HDL and high LDL cholesterol levels were characterized as the MHOO phenotype. A composite healthy lifestyle index (HLI) was constructed by including temporary changes in 3 lifestyle variables (diet, leisure-time physical activity, and smoking).Initially, 20.8% of subjects had the MHOO phenotype; 49.2% of these shifted to MAOO phenotype. In multivariate analysis, changes in BMI, WC, WHtR were positively associated (p = 0.004, p = 0.018, and p = 0.016, respectively) with this transition. One unit increase in the HLI was associated with a 33% lower risk (p = 0.025) to the MAOO phenotype transition after adjusting for age, sex, educational level, and baseline energy intake, BMI, WC, and WHtR.The presence of metabolic disorders in the MHOO phenotype is predicted by an increase in anthropometric surrogate measures of general and abdominal adiposity. In contrast, a healthy lifestyle protects against a transition to the MAOO phenotype.
- Subjects :
- Adult
Blood Glucose
Male
medicine.medical_specialty
Cross-sectional study
Population
Medicine (miscellaneous)
Motor Activity
Overweight
White People
Body Mass Index
Waist–hip ratio
Risk Factors
Surveys and Questionnaires
Internal medicine
medicine
Humans
Obesity
Prospective Studies
education
Prospective cohort study
Life Style
Triglycerides
Aged
Metabolic Syndrome
Waist-to-height ratio
education.field_of_study
Nutrition and Dietetics
Waist-Hip Ratio
business.industry
Metabolic disorder
nutritional and metabolic diseases
Feeding Behavior
Middle Aged
medicine.disease
Diet
Cholesterol
Cross-Sectional Studies
Endocrinology
Cardiovascular Diseases
Spain
Female
Waist Circumference
medicine.symptom
business
Body mass index
Follow-Up Studies
Subjects
Details
- ISSN :
- 14366215 and 14366207
- Volume :
- 53
- Database :
- OpenAIRE
- Journal :
- European Journal of Nutrition
- Accession number :
- edsair.doi.dedup.....c436d1484c6827e81536ca097f3257b8