A dimeric peptide alkaloid of a completely new type, Anchinopeptolide A, from the marine sponge Anchinoe tenacior

Anchinopeptolide A ( 1 ), a dimeric peptide alkaloid of a completely new type, has been isolated from the marine sponge Anchinoe tenacior collected in the Mediterranean sea along the coasts of Tunisia. The structure elucidation of 1 , which include in each half a C-terminal trans 4-hydroxystirylamino residue linked to L-alanine, which in turn is attached to an arginine derived 5-guanidino-2-hydroxy-pentanoyl residue, is described.