Back to Search
Start Over
Combinatorial Tethering: A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development
- Source :
- Zeisig, B B & So, C W E 2016, ' Combinatorial Tethering : A Novel Mode to Recruit Non-canonical PRC1 for Normal and Malignant GC B Cell Development ', CANCER CELL, vol. 30, no. 2, pp. 185-187 . https://doi.org/10.1016/j.ccell.2016.07.014
- Publication Year :
- 2016
-
Abstract
- The EZH2 histone methyltransferase mediates the humoral immune response and drives lymphomagenesis through formation of bivalent chromatin domains at critical germinal center (GC) B cell promoters. Herein we show that the actions of EZH2 in driving GC formation and lymphoma precursor lesions require site-specific binding by the BCL6 transcriptional repressor and the presence of a non-canonical PRC1-BCOR-CBX8 complex. The chromodomain protein CBX8 is induced in GC B cells, binds to H3K27me3 at bivalent promoters, and is required for stable association of the complex and the resulting histone modifications. Moreover, oncogenic BCL6 and EZH2 cooperate to accelerate diffuse large B cell lymphoma (DLBCL) development and combinatorial targeting of these repressors results in enhanced anti-lymphoma activity in DLBCLs.
- Subjects :
- 0301 basic medicine
Cancer Research
Polycomb-Group Proteins
macromolecular substances
Biology
Article
03 medical and health sciences
immune system diseases
hemic and lymphatic diseases
medicine
Humans
B cell
Genetics
B-Lymphocytes
Tethering
Germinal center
Cancer
BCL6
medicine.disease
Germinal Center
Cell biology
030104 developmental biology
medicine.anatomical_structure
Oncology
Non canonical
Cancer cell
PRC1
Subjects
Details
- ISSN :
- 18783686
- Volume :
- 30
- Issue :
- 2
- Database :
- OpenAIRE
- Journal :
- Cancer cell
- Accession number :
- edsair.doi.dedup.....c4290a6026588accd53aff2f9322be4b