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BAFF and the regulation of B cell survival
- Source :
- Immunology Letters. 88:57-62
- Publication Year :
- 2003
- Publisher :
- Elsevier BV, 2003.
-
Abstract
- The TNF family member BAFF is a fundamental survival factor for B cells. BAFF binds to three receptors, only one of which, BAFF-R, does not cross-react with the BAFF-related ligand APRIL. The survival function of BAFF on B cells is mediated mainly by BAFF-R and is particularly effective in transitional B cells. BAFF depletion leads to a considerable decrease in mature B cells, without apparent effect on B cell genesis. Consistently, BAFF overexpression results in an expanded B cell compartment and autoimmunity in mice. Elevated amounts of BAFF can be found in the serum of patients suffering from autoimmune diseases. The BAFF system is a promising target for the treatment of autoimmune diseases.
- Subjects :
- Cell Survival
Cellular differentiation
Tumor Necrosis Factor Ligand Superfamily Member 13
Immunology
B-Lymphocyte Subsets
Autoimmunity
Biology
medicine.disease_cause
Receptors, Tumor Necrosis Factor
Immune tolerance
Mice
stomatognathic system
immune system diseases
hemic and lymphatic diseases
B-Cell Activating Factor
Immune Tolerance
medicine
Animals
Humans
Immunology and Allergy
skin and connective tissue diseases
B-cell activating factor
Receptor
BAFF receptor
B cell
Tumor Necrosis Factor-alpha
Membrane Proteins
Cell Differentiation
stomatognathic diseases
medicine.anatomical_structure
Signal transduction
B-Cell Activation Factor Receptor
Signal Transduction
Subjects
Details
- ISSN :
- 01652478
- Volume :
- 88
- Database :
- OpenAIRE
- Journal :
- Immunology Letters
- Accession number :
- edsair.doi.dedup.....c42674e098506111f2f638c7dfafa850
- Full Text :
- https://doi.org/10.1016/s0165-2478(03)00050-6