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Synthesis and structure-activity relationships of sinenxan A derivatives as multidrug resistance reversal agents
- Source :
- Bioorganicmedicinal chemistry letters. 20(18)
- Publication Year :
- 2010
-
Abstract
- Two types of sinenxan A derivatives with different side chains at C-5 were synthesized and evaluated for their in vitro multidrug resistant reversal activities. Several derivatives exhibited better activities than the positive control verapamil. The structure-activity relationships of these derivatives suggested that a carbonyl group at C-13 and the length of side chain at C-5 are important for the activity.
- Subjects :
- Stereochemistry
Clinical Biochemistry
Pharmaceutical Science
Acetates
Biochemistry
Chemical synthesis
Structure-Activity Relationship
Neoplasms
Drug Discovery
Side chain
Tumor Cells, Cultured
Chemosensitizing agent
Structure–activity relationship
Humans
Cytotoxicity
Molecular Biology
Chemistry
Alkaloid
Organic Chemistry
Calcium Channel Blockers
In vitro
Drug Resistance, Multiple
Multiple drug resistance
Verapamil
Molecular Medicine
Diterpenes
Taxus
Subjects
Details
- ISSN :
- 14643405
- Volume :
- 20
- Issue :
- 18
- Database :
- OpenAIRE
- Journal :
- Bioorganicmedicinal chemistry letters
- Accession number :
- edsair.doi.dedup.....c41b6021df6994ea810a9fcb814cd688