Back to Search
Start Over
Iodine levels and thyroid hormones in healthy pregnant women and birth weight of their offspring
- Source :
- European journal of endocrinology. 160(3)
- Publication Year :
- 2008
-
Abstract
- IntroductionThe fetus is most vulnerable to severe iodine deficiency and hypothyroidism during pregnancy. The effects of mild iodine deficiency and subclinical hypothyroidism are poorly known. The present study assesses the association between thyroid hormones (TH)s and urinary iodine concentration (UIC) in healthy pregnant women and the birth weight of their children.MethodsAbout 657 pregnant women were recruited in Sabadell and followed until delivery. The association between THs during the first trimester, UIC during the first and third trimesters, and birth weight was studied in 557, 251, and 528 mother–newborn pairs respectively, using linear and logistic regression models adjusted for potential confounders. Only 239 women had all the data available (thyroid function and UIC at the first and third trimesters). Six percent of newborns were classified as small for gestational age (SGA).ResultsThe median UIC was 95 and 104 μg/l during the first and third trimesters respectively. Women with the third trimester UICs between 100 and 149 μg/l had lower risk of having an SGA newborn than women with UICs below 50 μg/l (adjusted OR (95%CI): 0.15 (0.03–0.76). There was no significant reduction in SGA among mothers with higher UICs. Lower free thyroxine and higher TSH levels during the first trimester were not associated with birth weight or SGA. Nevertheless, the analyses were repeated including only those women with all the data available, and high TSH levels became statistically significantly associated with lower birth weight and higher risk of SGA.ConclusionsThe present study suggests that iodine status during pregnancy may be related to prenatal growth in healthy women.
- Subjects :
- Adult
medicine.medical_specialty
Offspring
Endocrinology, Diabetes and Metabolism
Birth weight
Pregnancy Trimester, Third
Thyrotropin
Lower risk
Endocrinology
Hypothyroidism
Pregnancy
Risk Factors
Internal medicine
medicine
Birth Weight
Humans
business.industry
Infant, Newborn
General Medicine
medicine.disease
Iodine deficiency
Pregnancy Complications
Pregnancy Trimester, First
Thyroxine
Logistic Models
Infant, Small for Gestational Age
Linear Models
Gestation
Small for gestational age
Female
Thyroid function
business
Iodine
Subjects
Details
- ISSN :
- 1479683X
- Volume :
- 160
- Issue :
- 3
- Database :
- OpenAIRE
- Journal :
- European journal of endocrinology
- Accession number :
- edsair.doi.dedup.....c419b19159ca52101033aad71d3b96a2